Dianne F. Calkins

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The brain tissue is an important target for anti-HIV drug therapy. Since the permeability of the blood–brain and blood–cerebrospinal fluid (CSF) barriers may differ between neonates and adults, we have determined the effect of age on the distribution of zidovudine (ZDV or azidothymidine) into the CSF in the macaque (M. nemestrina). Five newborn macaques(More)
Return of sensory nerve function in rat molars following cut or crush injury to the inferior alveolar nerve (IAN) was measured by observing the jaw opening reflex (JOR) response of the digastric muscle to electrical stimulation of individual molars or the gingiva. The IAN was injured from a lateral approach to the mandibular ramus at a site approximately 2(More)
Hypoosmolar solutions were recently shown to produce a reversible conduction block of rabbit vagus nerve and to potentiate local anesthetic agents. The object of the present study was to determine the ability of neural tissue to recover structurally and functionally following exposure to hypoosmotic solutions. Cervical vagus nerves of rabbits were bathed in(More)
Inhalation anesthetics have been shown to substantially diminish the clearance of several drugs eliminated by hepatic routes. The purpose of the present study was to determine the influence of halothane-oxygen anesthesia on the hepatic metabolism of diazepam and its proximate metabolites in anesthetized rats whose physiologic status was monitored and(More)