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A Heparin Purification Process Removes Spiked Transmissible Spongiform Encephalopathy Agent

• Cyrus K Bett, Ksenija Grgac, +4 authors Luisa L. Gregori
• The AAPS Journal
• 2017

In 2000, bovine heparin was withdrawn from the US market for fear of contamination with bovine spongiform encephalopathy (BSE) agent, the cause of variant Creutzfeldt-Jakob disease in humans. Thus,… (More)

Simple NMR methods for evaluating higher order structures of monoclonal antibody therapeutics with quinary structure.

• Kang Chen, Dianna S Long, Scott C Lute, Michaella J. Levy, Kurt A. Brorson, David A. Keire
• Journal of pharmaceutical and biomedical analysis
• 2016

Monoclonal antibody (mAb) drugs constitute the largest class of protein therapeutics currently on the market. Correctly folded protein higher order structure (HOS), including quinary structure, is… (More)

Deep-Ultraviolet Resonance Raman (DUVRR) Spectroscopy of Therapeutic Monoclonal Antibodies Subjected to Thermal Stress.

• Justin Bueno, Dianna S Long, John F Kauffman, Sergey Arzhantsev
• Analytical chemistry
• 2015

The structural assessment of Rituximab, an IgG1 mAb, was investigated with deep-ultraviolet resonance Raman (DUVRR) spectroscopy. DUVRR spectroscopy was used to monitor the changes to the secondary… (More)

Synthesis and detection of N-sulfonated oversulfated chondroitin sulfate in marketplace heparin.

• Daniel J Mans, Hongping Ye, +7 authors David A. Keire
• Analytical biochemistry
• 2015

N-sulfonated oversulfated chondroitin sulfate (NS-OSCS), recently reported as a potential threat to the heparin supply, was prepared along with its intermediate derivatives. All compounds were spiked… (More)

Abortion choices among women in Cambodia after introduction of a socially marketed medicated abortion product.

• Khim Sotheary, Dianna S Long, Gary Mundy, Yasmin Madan, Paul D. Blumenthal
• International journal of gynaecology and…
• 2017

OBJECTIVE To assess whether a social marketing initiative focusing on medicated abortion via a mifepristone/misoprostol "combipack" has contributed to reducing unsafe abortion in Cambodia. METHODS… (More)

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