Diane Tuyishimire

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OBJECTIVE To determine the long-term outcomes of treatment and prevalence of genotypic drug resistance in children and adolescents on combination antiretroviral therapy. METHODS A cross-sectional study (September 2009 to October 2010) in which clinical, immunologic and virologic outcomes were assessed at a single-study visit and through patient records in(More)
OBJECTIVE The aim of this study was to determine the prevalence of hepatitis B virus (HBV) infection in a cohort of HIV-infected Rwandan children and adolescents on combination antiretroviral therapy (cART), and the success rate of HBV vaccination in those children found to be HBV negative. METHODS HIV-infected children and adolescents (age 8-17 years)(More)
This study evaluated mid-dosing interval efavirenz plasma concentrations and the influence of CYP2B6 polymorphisms in relation to efficacy, tolerability, and adherence in 97 Rwandan HIV-infected children (3-16 years). Plasma drug concentrations and CYP2B6 polymorphisms were determined. Ten children were excluded for nonadherence. Large intersubject(More)
BACKGROUND With increased availability of paediatric combination antiretroviral therapy (cART) in resource limited settings, cART outcomes and factors associated with outcomes should be assessed. METHODS HIV-infected children <15 years of age, initiating cART in Kigali, Rwanda, were followed for 18 months. Prospective clinical and laboratory assessments(More)
Results The mean ages (+/-SD) of the girls and boys were 16.3 +/0.165 years. About disclosure: 8.7% of the adolescents were not willing to disclose their HIV status to their sexual partners, yet 76% of interviewed have a partner. About safe sex: Overall, 8.4% of adolescent are sexually active all above 15years (4.4% of the girls and 12% of the boys). Boys(More)
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