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- Timothy M Coskran, Daniel Morton, +6 authors Diane Stephenson
- The journal of histochemistry and cytochemistry…
- 2006
A monoclonal antibody directed against the amino terminal of rat phosphodiesterase 10A (PDE10A) was used to localize PDE10A in multiple central nervous system (CNS) and peripheral tissues from mouse,… (More)
- Diane Stephenson, Douglas A Schober, E. Barry Smalstig, Ron E. Mincy, Donald R. Gehlert, James A. Clemens
- The Journal of neuroscience : the official…
- 1995
In mammalian brain the expression of peripheral benzodiazepine receptors (PBRs) can be markedly induced following different types of neuronal injury. PBRs are believed to be expressed on non-neuronal… (More)
- Zhi Yao Xie, Wendy O Adamowicz, +7 authors Frank S. Menniti
- Neuroscience
- 2006
PDE10A is a recently identified phosphodiesterase that is highly expressed by the GABAergic medium spiny projection neurons of the mammalian striatum. Inhibition of PDE10A results in striatal… (More)
- Diane Stephenson, Karen Rash, +7 authors James Clemens
- Glia
- 1999
Many recent studies have emphasized the deleterious role of inflammation in CNS injury. Increases in free fatty acids, eicosanoids, and products of lipid peroxidation are known to occur in various… (More)
- Diane Stephenson, Tim M Coskran, +6 authors Daniel Morton
- The journal of histochemistry and cytochemistry…
- 2009
Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. PDE2A is an evolutionarily… (More)
- Binhui Ni, Xiaolin Wu, +4 authors Steven M Paul
- Journal of cerebral blood flow and metabolism…
- 1998
The authors recently cloned a cDNA for an ICE/CED3-related cysteine protease from rat brain, which is closely related to human CPP32 (now designated caspase-3). In situ hybridization histochemistry… (More)
- Diane Stephenson, Cynthia A Lemere, Dennis J Selkoe, James A. Clemens
- Neurobiology of disease
- 1996
Phospholipase A2 (PLA2) is the key enzyme that initiates the arachidonic acid cascade, which leads to the generation of multiple eicosanoid products. Many of these products are believed to play an… (More)
BACKGROUND AND PURPOSE
After global ischemia, brain levels of hydrogen peroxide, oxygen radicals, and the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) are… (More)
- Diane Stephenson, Karen Rash, James A. Clemens
- Brain Research
- 1992
The distribution of beta-amyloid precursor protein (APP) was examined immunocytochemically in rats subjected to focal cerebral ischemia by permanent occlusion of the middle cerebral artery. At 4 and… (More)
- James A. Rogers, Daniel Polhamus, +6 authors Brian Corrigan
- Journal of Pharmacokinetics and Pharmacodynamics
- 2012
Our objective was to develop a beta regression (BR) model to describe the longitudinal progression of the 11 item Alzheimer’s disease (AD) assessment scale cognitive subscale (ADAS-cog) in AD… (More)