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In this work, we present a new fovea center detection method for color eye fundus images. This method is based on known anatomical constraints on the relative locations of retina structures, and mathematical morphology. The detection of this anatomical feature is a prerequisite for the computer aided diagnosis of several retinal diseases, such as Diabetic(More)
The identification of some important retinal anatomical regions is a prerequisite for the computer aided diagnosis of several retinal diseases. In this paper, we propose a new adaptive method for the automatic segmentation of the optic disk in digital color fundus images, using mathematical morphology. The proposed method has been designed to be robust(More)
The detection of exudates is a prerequisite for detecting and grading severe retinal lesions, like the diabetic macular edema. In this work, we present a new method based on mathematical morphology for detecting exudates in color eye fundus images. A preliminary evaluation of the proposed method performance on a known public database, namely DIARETDB1,(More)
PURPOSE The purpose of this study is to evaluate the efficacy of allogenic conjunctival transplantation in bilateral surface disorders and to correlate with human leukocyte antigen (HLA) typing and cross-matching. METHODS A prospective study of allogenic conjunctival transplantation was undertaken in 12 eyes of 10 patients with bilateral surface(More)
This paper presents data collected by a Brazilian center in a multinational multicenter observational study of patients with mucopolysaccharidosis type VI (MPS VI), aiming at determining the epidemiological, clinical, and biochemical profile of these patients. Twenty-eight south-American patients with MPS VI were evaluated through medical interview,(More)
BACKGROUND Favorable results have been obtained by the use of deep-frozen bone allografts in total hip arthroplasty. However, owing to the shortage of deep-frozen allografts and the risk of infectious disease, other materials have been studied, such as sterile nondemineralized freeze-dried allografts. The aim of this study was to describe midterm clinical(More)
Mucopolysaccharidoses (MPS) are rare genetic diseases caused by deficiency of specific lysosomal enzymes that affect catabolism of glycosaminoglycans (GAG). Accumulation of GAG in various organs and tissues in MPS patients results in a series of signs and symptoms, producing a multisystemic condition affecting bones and joints, the respiratory and(More)
Mucopolysaccharidoses (MPS) are rare genetic diseases caused by the deficiency of one of the lysosomal enzymes involved in the glycosaminoglycan (GAG) breakdown pathway. This metabolic block leads to the accumulation of GAG in various organs and tissues of the affected patients, resulting in a multisystemic clinical picture, sometimes including cognitive(More)
A new adaptive morphological method for the automatic detection of the optic disk in digital color eye fundus images is presented in this paper. This method has been designed to detect the optic disk center and the optic disk rim. In our experiments with the DRIVE and DIARETDB1 databases, the proposed method was able to detect the optic disk center with(More)
BACKGROUND Precise IOL calculation in post-refractive surgery patients is still a challenge for the cataract surgeon. The purpose of this study is to test whether adding Orbscan II values into the double-K method improves IOL calculation in this group of patients. METHODS A prospective study with 43 eyes previously submitted to refractive surgery that(More)