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  • Diane R Mould, Richard N Upton
  • Medicine
  • CPT: pharmacometrics & systems pharmacology
  • 2013 (First Publication: 1 April 2013)
  • Population pharmacokinetic models are used to describe the time course of drug exposure in patients and to investigate sources of variability in patient exposure. They can be used to simulateContinue Reading
  • Diane R Mould, Antoine Baumann, +6 authors Peter L Bonate
  • Medicine
  • British journal of clinical pharmacology
  • 2007 (First Publication: 1 September 2007)
  • AIMS To characterize alemtuzumab pharmacokinetics and its exposure-response relationship with white blood cell (WBC) count in patients with B-cell chronic lymphocytic leukaemia (CLL). METHODSContinue Reading
  • Iris Dotan, Yulia Ron, +5 authors Diane R Mould
  • Medicine
  • Inflammatory bowel diseases
  • 2014 (First Publication: 1 December 2014)
  • BACKGROUND Infliximab (IFX) is effective therapy for ulcerative colitis and Crohn's disease, but it may be associated with side effects and loss of response. One loss of response mechanism isContinue Reading