Diane M Austin

Learn More
BACKGROUND Sleep duration may be an important regulator of body weight and metabolism. An association between short habitual sleep time and increased body mass index (BMI) has been reported in large population samples. The potential role of metabolic hormones in this association is unknown. METHODS AND FINDINGS Study participants were 1,024 volunteers(More)
BACKGROUND Sleep-disordered breathing (SDB) is a treatable but markedly under-diagnosed condition of frequent breathing pauses during sleep. SDB is linked to incident cardiovascular disease, stroke, and other morbidity. However, the risk of mortality with untreated SDB, determined by polysomnography screening, in the general population has not been(More)
Menopause is considered to be a risk factor for sleep-disordered breathing, but this hypothesis has not been adequately tested. The association of premenopause, perimenopause, and postmenopause with sleep-disordered breathing was investigated with a population-based sample of 589 women enrolled in the Wisconsin Sleep Cohort Study. Menopausal status was(More)
STUDY OBJECTIVES Increasing evidence suggests that alterations in sleep duration are associated with cardiovascular disease (CVD) and mortality. Additionally, sleep disordered breathing (SDB), which is associated with disturbed nighttime sleep and hypoxemia, may be an independent risk factor for CVD. The inflammatory marker, C-reactive protein (CRP), is an(More)
RATIONALE Cross-sectional association has been reported between sleep-disordered breathing (SDB) and insulin resistance, but no prospective studies have been performed to determine whether SDB is causal in the development of diabetes. OBJECTIVES The purpose of our study was to investigate the prevalence and incidence of type II diabetes in subjects with(More)
STUDY OBJECTIVE Assess objectively measured sleep quality in premenopausal, perimenopausal, and postmenopausal women. DESIGN Observational epidemiology study. SETTING Community-based. PARTICIPANTS Probability sample of 589 premenopausal, perimenopausal, and postmenopausal women recruited from state employee records. INTERVENTIONS None. (More)
STUDY OBJECTIVES Experimental evidence indicates that alcohol use near bedtime may exacerbate sleep disordered breathing (SDB). However, scarce research has examined the relation between moderate habitual alcohol use and objectively assessed SDB, and it is unclear whether patients with SDB, or those at risk for SDB, should be counseled to avoid alcohol(More)
BACKGROUND The objective of this study was to measure subject perspective and reaction to participation in the Personalized Medicine Research Project (PMRP) and to identify factors predicting understanding of the study elements. METHOD Self-administered questionnaires were mailed to 1,593 subjects (10% sample). The questionnaire had three sections:(More)
The purpose of this research was to investigate the reproductive capacity (i.e., the ability to successfully transfer an ejaculate and induce a progestational response in the female) of male laboratory rats (Rattus norvegicus). Males were individually mated to successive females in a single session for one ejaculatory series each. There was a marked decline(More)
OBJECTIVE To determine whether unobtrusive long-term in-home assessment of walking speed and its variability can distinguish those with mild cognitive impairment (MCI) from those with intact cognition. METHODS Walking speed was assessed using passive infrared sensors fixed in series on the ceiling of the homes of elderly individuals participating in the(More)