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  • R Franz, Steven L Kelly, David C. Lamb, Diane Kelly, Markus Ruhnke, Joachim Morschhäuser
  • Biology, Medicine
  • Antimicrobial agents and chemotherapy
  • 1998 (First Publication: 1 December 1998)
  • From each of two AIDS patients with oropharyngeal candidiasis, five Candida albicans isolates from recurrent episodes of infection which became gradually resistant against fluconazole duringContinue Reading
  • David C. Lamb, Diane Kelly, +5 authors Steven L Kelly
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1997 (First Publication: 28 February 1997)
  • Sterol 14alpha-demethylase (P45051) is the target for azole antifungal compounds, and resistance to these drugs and agrochemicals is of significant practical importance. We undertook site-directedContinue Reading
  • Stephen L. Kelly, David C. Lamb, +5 authors H. Einsele
  • Medicine, Biology
  • FEBS letters
  • 1997 (First Publication: 2 January 1997)
  • Fluconazole resistance occurs in > 10% of cases of candidosis during the late stages of AIDS. We show here in two clinical isolates that resistance was caused by defective sterolContinue Reading
  • Steven L Kelly, David C. Lamb, Andrew J. Corran, Brian C. Baldwin, Diane Kelly
  • Biology
  • 1995 (First Publication: 1 February 1995)
  • Abstract Azole antifungal compounds inhibit sterol 14α-demethylase. They are used extensively for the treatment of immunocompromised patients where fungal infection is common and often results inContinue Reading
  • Steven L Kelly, Diane Kelly
  • Medicine, Biology
  • Philosophical Transactions of the Royal Society B…
  • 2013 (First Publication: 19 February 2013)
  • The first eukaryote genome revealed three yeast cytochromes P450 (CYPs), hence the subsequent realization that some microbial fungal genomes encode these proteins in 1 per cent or more of all genesContinue Reading