Diane E. Mapstone

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A nuclear matrix (NM)-associated region (MAR) of the protooncogene c-myc is identified in a human leukemia cell line (HL-60). A binding assay between isolated NM and 32P-end-labeled c-myc fragments in the presence of unlabeled competitors was used, and a 3'-end DraI/DraI fragment of 172 base pairs containing the first of the two polyadenylation [poly(A)](More)
HL-60 cells, a human promyelocytic leukemia cell line, contain amplified c-myc DNA sequences and mRNA transcripts. These cells can be induced to undergo macrophage differentiation by phorbol esters, which results in suppression of c-myc expression and cessation of cell proliferation. The nuclear matrix (NM), a nuclear skeleton resistant to DNase I digestion(More)
A nuclear matrix (NlVl)-associated region (MAR) of the protooncogene c-myc is identified in a human leukemia cell line (HL-60). A binding assay between isolated NM and '"P-end-labeled c-myc fragments in the presence of unlabeled competitors was used, and a 3'-end Oral/Oral fragment of 172 base pairs containing the first of the two polyadenylation [poly(A)](More)
A nuclear matrix (NlVl)-associated region (MAR) of the protooncogene c-myc is identified in a human leukemia cell line (HL-60). A binding assay between isolated NM and '"P-end-labeled c-myc fragments in the presence of unlabeled competitors was used, and a 3'-end Oral/Oral fragment of 172 base pairs containing the first of the two polyadenylation [poly(A)](More)
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