Diane E J Stafford

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Blood pressure was recorded during fatiguing and nonfatiguing isometric contractions of a slow-twitch muscle (the soleus) and a mixed muscle (the medial gastrocnemius) of the cat. Four tensions were examined in each muscle; 10, 25, 40, and 70% of the muscle's initial strength (tetanic tension of the unfatigued muscle). All experiments were also repeated at(More)
The human GnRH (hGnRH) gene is expressed, and the GnRH decapeptide produced, primarily in the GnRH neurons of the diencephalon. The molecular elements important for the cell-specific expression and regulation of the hGnRH gene are not well established at this time; therefore, we have used a transgenic mouse model to isolate cis-regulatory elements important(More)
The purpose of the present study was to define a comprehensive approach to the rehabilitation of the paralyzed individual. Consequently, we have examined the cardiopulmonary effects of active physical therapy (APT) (as measured by blood pressure [BP], heart rate [HR], equivalent ventilatory rate [ VE], oxygen consumption rate [VO2], blood lactate [LA], and(More)
476 Br J Sports Med June 2010 Vol 44 No 7 there may be considerable rewards, individual fame or national prestige associated with winning, not only for the athlete but for the coach and his or her entourage. These competitions also represent important showgrounds for young athletes; in some sports, this is often where talented athletes are identifi ed for a(More)
Mutations in the high-affinity sulfonylurea receptor (SUR)-1 cause one of the severe recessively inherited diffuse forms of congenital hyperinsulinism or, when associated with loss of heterozygosity, focal adenomatosis. We hypothesized that SUR1 mutations would render the beta-cell insensitive to sulfonylureas and to glucose. Stimulated insulin responses(More)
Fellows are expected to educate trainees, peers, and patients, during and long after fellowship. However, there has been relatively little emphasis on the acquisition of teaching skills in fellowship programs. Challenges to teaching by fellows during subspecialty training include demanding clinical duties, their limited knowledge base in the field, brief(More)
The muscle blood flow, oxygen uptake, carbon dioxide production, muscle and blood lactate, muscle ATP, creatinine phosphate, glycogen, and venous pH were measured in the soleus (a slow-twitch muscle) and the medial gastrocnemius (a fast-twitch muscle) of the cat during fatiguing isometric exercise. Five tensions were examined: 10, 25, 50, 75, and 100% of(More)
A basic closed loop control system is described for controlling movement of paralyzed skeletal muscle in humans. The system is based around a Z80 microprocessor with 20K of memory. The system involves sensors to detect the amount of movement in muscle or the tension generated by that muscle, a computer-controlled stimulator, and electrodes placed on the(More)
OBJECTIVE To assess medical resource utilization associated with Prader-Willi syndrome (PWS) in the US, hypothesized to be greater relative to a matched control group without PWS. STUDY DESIGN We used a retrospective case-matched control design and longitudinal US administrative claims data (MarketScan) during a 5-year enrollment period (2009-2014).(More)
PURPOSE OF REVIEW Polycystic ovary syndrome is one of the most common endocrinopathies affecting premenopausal women. This review focuses on this major cause of hyperandrogenism in adolescents and young women, highlighting new diagnostic and therapeutic strategies that are under investigation. The pathophysiologic role in the disorder are the subject of(More)