Diane B. Howieson

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OBJECTIVE To determine initial locus and rate of degeneration of temporal lobe structures (total lobe, hippocampus and parahippocampus) in preclinical dementia. BACKGROUND Postmortem studies suggest that the earliest changes in Alzheimer's disease are neurofibrillary tangle formation in hippocampus and adjacent cortex. MRI volume analysis of temporal lobe(More)
OBJECTIVE To look for preclinical markers of Alzheimer's dementia in a sample of healthy, oldest old individuals. DESIGN Prospective, longitudinal study of individuals examined at yearly intervals with neuropsychological tests selected to be sensitive to the early detection of dementia. PARTICIPANTS One hundred and thirty-nine community-dwelling,(More)
Eighty-five healthy elderly subjects were prospectively evaluated for 3 years to determine motor differences between those who remain cognitively intact and those who developed cognitive impairment during prospective follow-up. The 18 subjects who developed cognitive impairment had slower finger tapping and took longer to walk 30 feet before or at the time(More)
BACKGROUND Several studies have shown that individually memory, hippocampal volume, and motor measures presage the onset of dementia. It is unclear if these independently contribute to the prediction of mild cognitive impairment. OBJECTIVE To determine the ability of memory, hippocampal volume, and a gait speed to independently predict cognitive decline(More)
BACKGROUND The use of volumetric MRI as a biomarker for assessing transitions to dementia presumes that more rapid brain loss marks the clinical transition from benign aging to mild cognitive impairment (MCI). The trajectory of this volume loss relative to the timing of the clinical transition to dementia has not been established. METHODS The authors(More)
Human tests designed to mirror rodent tests of object recognition and spatial navigation were administered to adult cognitively healthy humans. Facial recognition was also assessed. There was no sex difference in facial recognition, consistent with earlier studies. In the object recognition test, the test-retest NINL total scores during the same visit were(More)
BACKGROUND White matter hyperintensity (WMH) change on brain MRI is observed with increased frequency in the elderly and has been independently associated with neurologic decline. The degree to which the location and rate of volume increase in WMH affects other structural brain changes along with cognitive and motor performance over time may determine(More)
OBJECTIVE To determine which vascular pathology measure most strongly correlates with white matter hyperintensity (WMH) accumulation over time, and whether Alzheimer disease (AD) neuropathology correlates with WMH accumulation. METHODS Sixty-six older persons longitudinally followed as part of an aging study were included for having an autopsy and >1 MRI(More)
OBJECTIVE To determine which brain regions lose volume with aging over time in healthy, nondemented elderly. BACKGROUND Cross-sectional studies suggest widespread loss of brain volume with aging. These studies may be biased by significant numbers of preclinically demented elderly in the oldest comparison groups. Longitudinal studies may allow closer(More)
OBJECTIVE To identify the MRI imaging findings associated with motor changes in healthy older people. DESIGN A cross-sectional study. SETTING A study of neurologic function in very healthy older people, the Oregon Brain Aging Study. PARTICIPANTS Clinical and MRI data were examined in 50 very healthy older subjects (mean age = 85.1, SD = 7.2 years). (More)