Diana van Netten

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Tuberous sclerosis is an autosomal dominant human disorder caused by inactivating mutations to either the TSC1 or TSC2 tumour suppressor gene. Hamartin and tuberin, the TSC1 and TSC2 gene products, interact and the tuberin–hamartin complex inhibits cell growth by antagonising signal transduction to downstream effectors of the mammalian target of rapamycin(More)
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