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The active length-tension curves of identified single motor units (MUs) belonging to peroneus longus muscle (PL) of anaesthetized adult cats were obtained by eliciting isometric single twitches and tetani. The recorded responses were evaluated by measuring the peak tension amplitude and the tension-time area at muscle lengths extending throughout the(More)
The anticarcinogenic properties of epsilon-aminocaproic acid were studied in two rat models of carcinogenesis. Esophageal tumors were induced by oral instillations of a total dose of 54 mg/kg body weight N-methyl-N-benzylnitrosamine whereas tumors of the nervous system and kidney-by transplacental injection of 75 mg/kg body weight N-ethyl-N-nitrosourea.(More)
The effects of indomethacin and dexamethasone on carcinogenesis of the esophagus and forestomach were studied in male rats. The rats were treated by N-nitrososarcosine ethyl ester (NSEE) per os in a daily dose of 50 mg/kg body weight for 16 weeks. Indomethacin (25 mg per kg of the food) and dexamethasone (1 mg per kg of the food) were added to food on(More)
The study was concerned with the influence of tocopherol and ascorbic acid on induction of tumors by N-nitrososarcosine ethyl ester (NSEE) in rats. In the first series of experiments, NSEE was given orally in the daily dose of 100 mg/kg body weight during 8 weeks while alpha-tocopherol acetate was administered in the dose of 600 mg/kg food during the(More)
The study was concerned with the influence of prolonged treatment with riboflavin, molybdenum, selenium and zinc on the induction of tumors of the esophagus and forestomach by N-nitrososarcosine ethyl ester (NSEE) in rats. Riboflavin was fed whereas molybdenum, selenium or zinc were given in drinking water after the discontinuation of treatment with NSEE,(More)
Immunostimulating synthetic peptide thymogen being an analog of the thymus polypeptide drug thymalin was studied for its effect on carcinogenesis of the esophagus and forestomach in male rats. Rats received N-nitrososarcosine ethyl ester (NSEE) per os in the daily dose of 100 mg/kg of body weight during 8 weeks. After cessation of the carcinogen(More)
Anticarcinogenic effects of the fumaric acid was studied in two rat models of carcinogenesis. Tumors of the esophagus, forestomach, tongue and throat were induced by peroral instillation of 35 mg/kg body weight N-methyl-N-benzylnitrosamine, and neurogenic and renal ones--by transplacental injection of 75 mg/kg body weight N-ethyl-N-nitrosourea. The fumaric(More)
The study was concerned with the inhibitory effect of officinal preparations of phytoadaptogenic drugs such as bioginseng and Eleutherococcus senticosus and Rhaponticum carthamoides root extracts on the carcinogenesis induced by transplacental administration of N-nitrosoethylurea. The phytodrugs were given orally over a year. The administration of the drugs(More)
The effects of nonsteroidal and steroidal drugs ortophen and dexamethasone on carcinogenesis of the uterine cervix and vagina were studied on mice. Intravaginal applications of a 0.1% solution of 7,12-dimethylbenz(a)anthracene, 2 times a week for 8 weeks, induced cervical and vaginal carcinomas in 67% of cases in 35 weeks. Ortophen (20 mg/l of drinking(More)
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