Diana Stefanescu

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The purpose of this study was to assess the impact of disseminated tumor cells (DTCs) on progression-free and overall survival (OS) in patients with metastatic breast cancer (MBC) and to compare it to simultaneous detection of circulating tumor cells (CTCs) from the blood in a subgroup. Disseminated tumor cells were identified in bone marrow (BM) aspirates(More)
p53 gene mutations are the most frequent alterations in human cancers. In the published literature, a highly significant statistical difference between the prevalence of p53 mutations in haematological (H) and non-haematological (NH) malignancies can be found. However, no consistent reasons have been suggested to explain it. We propose two non-exclusive(More)
The hematological malignancies evolution exhibits significant differences with the solid tissue tumor development, especially in the initiation step. The loss of negative regulation theory of carcinogenesis was unambiguously demonstrated in the field of colorectal neoplasia, but up to date, several lines of inquiry failed to imply the dysregulation of(More)
This paper presents a solution for conceptually modeling the training domain knowledge of computer-assisted instructional environments. A stringent requirement for an effective computer-assisted instructional environment is to elaborate a proper answer for the differentiated cognitive demands of users. The different cognitive style of learners imposes(More)