Diana M Batten

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The challenge of the postgenomic era is not only to assign functions to individual genes, but also to determine how sets of genes act in concert to control biological processes. This formidable task is even more daunting when one attempts to understand the complex genetic programs underlying nervous system development. More than half of the approximately(More)
Despite the promise of short interfering RNAs (siRNA), contending with off-target is a challenge for RNAi users. To alleviate these problems, we have developed locked nucleic acid (LNA) modified siRNAs and optimized performance using cellular phenotypic assays as well as microarray analysis. During development, we compared LNA and 2'OMethoxy (2'OMe)(More)
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