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We report here that PLC-gamma isoforms are required for agonist-induced Ca2+ entry (ACE). Overexpressed wild-type PLC-gamma1 or a lipase-inactive mutant PLC-gamma1 each augmented ACE in PC12 cells, while a deletion mutant lacking the region containing the SH3 domain of PLC-gamma1 was ineffective. RNA interference to deplete either PLC-gamma1 or PLC-gamma2(More)
Although the electrophysiological Japan properties of SOCs have been defined in certain cell types (Parekh and Penner, 1997), it is likely that several distinct channel activities mediate store-operated Ca 2ϩ Summary entry among different cells. Nevertheless, SOCs display some common features including a relatively slow rate We report here that PLC-␥(More)
This paper presents an alternative model to conventional feature filmmaking using <i>two different</i> games engines SIMS 2 and Half Life 2. This alternative method of narrative drama, i.e. telling stories via a hybrid machinima medium, is important in highlighting some of the potential that the new media 'auteur' approach provides individual filmmakers. By(More)
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