Diana Braun

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OBJECTIVES The therapeutic use of the vascular endothelial growth factor (VEGF) antagonist sunitinib is limited by sunitinib-induced hypertension. The hypotheses were tested that sunitinib increases renal vascular resistance (RVR) and renal Na+ reabsorption, and that Rho kinase (ROCK) inhibition blunts sunitinib-induced hypertension. METHODS Sunitinib(More)
BACKGROUND Vasa recta (VR) supply the inner part of outer renal medulla an area at risk for hypoxic damages. OBJECTIVE We hypothesize increased vasoreactivity after hypoxia/re-oxygenation (H/R) in VR, which might contribute to the reduced medullary perfusion after an ischemic event. METHODS Live kidney slices (200μm) from SD rats were used for(More)
We tested the hypothesis that hypoxia/reoxygenation (H/R) augments vasoreactivity to angiotensin II (Ang II). In particular, we compared an in situ live kidney slice model with isolated afferent arterioles (C57Bl6 mice) to assess the impact of tubules on microvessel response. H&E staining was used to estimate slice viability. Arterioles in the slices were(More)
AIM Afferent arterioles (AA) hold a key position in the regulation of renal blood flow and glomerular filtration rate. Being the effector site of tubuloglomerular feedback, the afferent arteriole contributes to the renal handling of sodium and fluid. Dehydration goes along with increased renal interstitial protein concentration. Here, the hypothesis was(More)
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