Diana Avery

Learn More
The epithelial sodium channel (ENaC) is composed of three homologous subunits termed alpha, beta, and gamma. Previous studies suggest that selected residues within a hydrophobic region immediately preceding the second membrane-spanning domain of each subunit contribute to the conducting pore of ENaC. We probed the pore of mouse ENaC by systematically(More)
The effects of injections of either bombesin (BBS) or cholecystokinin octapeptide (CCK-8) on patterns of food intake of macronutrients were examined in adult male rats, and compared to the effects following saline injections. The animals were food deprived for 18 hours and then offered one of three isocaloric dietary components (protein, carbohydrate or(More)
Cocaine was administered via an oral route to 18-h food deprived female rats for 14 consecutive days. Following administration of the drug or vehicle control each animal was presented with separate isocaloric rations of protein, fat, and carbohydrate in a dietary self-selection situation. Amounts consumed of each component were measured at 30 min, 60 min, 2(More)
Malignant cells drive the generation of a desmoplastic and immunosuppressive tumor microenvironment. Cancer-associated stromal cells (CASC) are a heterogeneous population that provides both negative and positive signals for tumor cell growth and metastasis. Fibroblast activation protein (FAP) is a marker of a major subset of CASCs in virtually all(More)
The effect of cocaine on spatial learning was investigated by exposing male Sprague-Dawley rats to 0, 20, or 40 mg/kg cocaine prior to and during training on a water maze task. Half the animals were pretrained on cued trials prior to hidden platform trials, while the remaining animals completed hidden platform trials immediately. Escape latencies for all(More)
The neuropeptide bombesin (BBS) is examined with regard to possible designation as an integrative peptide. The term integrative peptide has been proposed to distinguish a subset of regulatory peptides. These peptides, distributed in the body and the brain, may function as hormones and neurotransmitters to integrate physiological and psychological functions.(More)
The effects of peripheral systemic administration of urocortin on operant responding to obtain food were investigated using three separate concentrations. The drug was administered intraparitoneally at a concentration of 10 microg/ml/Kg, 5 microg/ml/Kg, and 0 microg/ml/Kg suspended in saline at a volume of 1 ml/Kg to Sprague-Dawley rats fifteen minutes(More)
Members of the cytomegalovirus family each encode two or more genes with significant homology to G-protein coupled receptors (GPCRs). In rodent models of pathogenesis, these viral encoded GPCRs play functionally significant roles, as their deletion results in crippled viruses that cannot traffic properly and/or replicate in virally important target cells.(More)
Bombesin is an oligopeptide which has been implicated as a possible neurotransmitter or neuromodulator in the central nervous system. Central administration of the peptide produces physiological and behavioral responses which suggest a downward shift in the set point of body temperature. These include hypothermia, decreased metabolic rate and increased(More)
The effects of intraperitoneal injections of cholecystokinin (CCK) and bombesin (BBS) on food-rewarded operant responding were investigated. Response rates were significantly suppressed following administrations of CCK (0.7, 1.4, and 2.9 micrograms/kg). The effects appeared to be dose dependent. Responding was also suppressed following injections of BBS (6(More)