Diamantis Sellis

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Molecular adaptation is typically assumed to proceed by sequential fixation of beneficial mutations. In diploids, this picture presupposes that for most adaptive mutations, the homozygotes have a higher fitness than the heterozygotes. Here, we show that contrary to this expectation, a substantial proportion of adaptive mutations should display heterozygote(More)
Adaptation in diploids is predicted to proceed via mutations that are at least partially dominant in fitness. Recently, we argued that many adaptive mutations might also be commonly overdominant in fitness. Natural (directional) selection acting on overdominant mutations should drive them into the population but then, instead of bringing them to fixation,(More)
An understanding of the distribution of natural patterns of genetic variation is relevant to such fundamental biological fields as evolution and development. One recent approach to understanding such patterns has been to focus on the constraints that may arise as a function of the network or pathway context in which genes are embedded. Despite theoretical(More)
Predicting adaptive evolutionary trajectories is a primary goal of evolutionary biology. One can differentiate between forward and backward predictability, where forward predictability measures the likelihood of the same adaptive trajectory occurring in independent evolutions and backward predictability measures the likelihood of a particular adaptive path(More)
12 Several recent experimental studies assessed the likelihood of all possible evolutionary 13 paths between ancestral and evolved sequences. All of these studies measured the fitness of 14 the intermediate genotypes and assumed that the advantageous genotypes fix in the 15 population before acquiring the next adaptive mutation along the path.(More)
Adaptation in diploids is predicted to proceed via mutations that are at least partially dominant in fitness. Recently we argued that many adaptive mutations might also be commonly overdominant in fitness. Natural (directional) selection acting on overdominant mutations should drive them into the population but then, instead of bringing them to fixation,(More)
Predicting adaptive evolutionary trajectories is a primary goal of evolutionary biology. One can differentiate between forward and backward predictability, where forward predictability measures the likelihood of the same adaptive trajectory occurring in independent evolutions and backward predictability measures the likelihood of a particular adaptive path(More)
12 Predicting the future evolutionary state of a population is a primary goal of evolutionary 13 biology. One can differentiate between forward and backward predictability, where forward 14 predictability is the probability of the same adaptive outcome occurring in independent 15 evolutionary trials, and backward predictability is the likelihood of a(More)
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