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Cryptococcus neoformans is a major cause of fungal meningitis in individuals with impaired immunity. Our previous studies have shown that the VPS41 gene plays a critical role in the survival of Cryptococcus neoformans under nitrogen starvation; however, the molecular mechanisms underlying VPS41-mediated starvation response remain to be elucidated. In the(More)
Cryptococcus neoformans is an important opportunistic human fungal pathogen infecting immunocompromised patients and commonly causes life-threatening cryptococcal meningitis. Previous studies have shown that the VPS41 gene plays an essential role in the starvation response, macrophage survival and pathogenicity of C. neoformans. Here we present evidence(More)
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