Di Wu

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Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

Elgene Lim, François Vaillant, +17 authors Geoffrey J Lindeman
Nature Medicine
2009

Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop from the mammary stem cell. To explore early… (More)

Control of mammary stem cell function by steroid hormone signalling

Marie-Liesse Asselin-Labat, François Vaillant, +8 authors Jane E. Visvader
Nature
2010

The ovarian hormones oestrogen and progesterone profoundly influence breast cancer risk, underpinning the benefit of endocrine therapies in the treatment of breast cancer. Modulation of their effects… (More)

Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury

Paul Lu, Yaozhi Wang, +11 authors Mark H Tuszynski
Cell
2012

Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells differentiated into… (More)

Camera: a competitive gene set test accounting for inter-gene correlation

Di Wu, Gordon K Smyth
Nucleic acids research
2012

Competitive gene set tests are commonly used in molecular pathway analysis to test for enrichment of a particular gene annotation category amongst the differential expression results from a… (More)

Isolation and culture of epithelial progenitors and mesenchymal stem cells from human endometrium.

Caroline E Gargett, Kjiana Elkje Schwab, Rachel M Zillwood, Hong P. T. Nguyen, Di Wu
Biology of reproduction
2009

Human endometrium is a highly regenerative tissue undergoing more than 400 cycles of growth, differentiation, and shedding during a woman's reproductive years. Endometrial regeneration is likely… (More)

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

Jian-Hua Mao, Jesus Perez-losada, +6 authors Allan Balmain
Nature
2004

The FBXW7/hCDC4 gene encodes a ubiquitin ligase implicated in the control of chromosome stability. Here we identify the mouse Fbxw7 gene as a p53-dependent tumour suppressor gene by using a mammalian… (More)

Prognostic Significance of Anaplastic Lymphoma Kinase (ALK) Protein Expression in Adults With Anaplastic Large Cell Lymphoma

Randy D. Gascoyne, Patricia A Aoun, +9 authors Dennis D. Weisenburger
Blood
1999

Anaplastic large cell lymphoma (ALCL) is an aggressive lymphoma that is frequently associated with the t(2;5)(p23;q35), resulting in expression of a fusion protein, nucleophosmin-anaplastic lymphoma… (More)

Topologically convergent and divergent structural connectivity patterns between patients with remitted geriatric depression and amnestic mild cognitive impairment.

Feng Bai, Ni Shu, +7 authors Zhi-Jun Zhang
The Journal of neuroscience : the official…
2012

Alzheimer's disease (AD) can be conceptualized as a disconnection syndrome. Both remitted geriatric depression (RGD) and amnestic mild cognitive impairment (aMCI) are associated with a high risk for… (More)

Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia

John C. Byrd, Thomas H S Lin, +17 authors Michael R Grever
Blood
2007

Despite promising preclinical studies with the cyclin-dependent kinase inhibitor flavopiridol in chronic lymphocytic leukemia (CLL) and other diseases, previous clinical trials with this agent have… (More)

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway.

Revati J. Tatake, Margaret M O'Neill, +7 authors Roger J Snow
Biochemical and biophysical research…
2008

We have identified two novel MEK5 inhibitors, BIX02188 and BIX02189, which inhibited catalytic function of purified, MEK5 enzyme. The MEK5 inhibitors blocked phosphorylation of ERK5, without… (More)

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