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—BitTorrent is the most successful open Internet application for content distribution. Despite its importance, both in terms of its footprint in the Internet and the influence it has on emerging P2P applications, the BitTorrent Ecosystem is only partially understood. We seek to provide a nearly complete picture of the entire public BitTorrent Ecosystem. To(More)
limma is an R/Bioconductor software package that provides an integrated solution for analysing data from gene expression experiments. It contains rich features for handling complex experimental designs and for information borrowing to overcome the problem of small sample sizes. Over the past decade, limma has been a popular choice for gene discovery through(More)
Competitive gene set tests are commonly used in molecular pathway analysis to test for enrichment of a particular gene annotation category amongst the differential expression results from a microarray experiment. Existing gene set tests that rely on gene permutation are shown here to be extremely sensitive to inter-gene correlation. Several data sets are(More)
In recent years, a lot of efforts have been made in conformational epitope prediction as antigen proteins usually bind antibodies with an assembly of sequentially discontinuous and structurally compact surface residues. Currently, only a few methods for spatial epitope prediction are available with focus on single residue propensity scales or continual(More)
Over the last few years, with the immense popularity of the Kinect, there has been renewed interest in developing methods for human gesture and action recognition from 3D skeletal data. A number of approaches have been proposed to extract representative features from 3D skeletal data, most commonly hard wired geometric or bio-inspired shape context(More)
Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop from the mammary stem cell. To explore early cellular changes that occur in BRCA1 mutation carriers, we have prospectively isolated distinct epithelial subpopulations from normal mammary tissue and(More)
Here, we report generation and characterization of Disrupted-In-Schizophrenia-1 (DISC1) genetically engineered mice as a potential model for major mental illnesses, such as schizophrenia. DISC1 is a promising genetic risk factor for major mental illnesses. In this transgenic model, a dominant-negative form of DISC1 (DN-DISC1) is expressed under the(More)
—This paper proposes an operating framework for ag-gregators of plug-in electric vehicles (PEVs). First, a minimum-cost load scheduling algorithm is designed, which determines the purchase of energy in the day-ahead market based on the forecast electricity price and PEV power demands. The same algorithm is applicable for negotiating bilateral contracts.(More)
MOTIVATION A gene set test is a differential expression analysis in which a P-value is assigned to a set of genes as a unit. Gene set tests are valuable for increasing statistical power, organizing and interpreting results and for relating expression patterns across different experiments. Existing methods are based on permutation. Methods that rely on(More)