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Demonstration of functional coupling between γ-aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles
  • H. Jin, H. Wu, +7 authors J. Wu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 12 March 2003
l-Glutamic acid decarboxylase (GAD) exists as both membrane-associated and soluble forms in the mammalian brain. Here, we propose that there is a functional and structural coupling between theExpand
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  • Open Access
Choline Acetyltransferase: Regulation and Coupling with Protein Kinase and Vesicular Acetylcholine Transporter on Synaptic Vesicles
Both the membrane-bound choline acetyltransferase (MChAT) and soluble ChAT (SChAT) were found to be activated by ATP-mediated protein phosphorylation. ATP activation of MChAT but not SChAT was foundExpand
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Mechanism of neuroprotective function of taurine.
Taurine has potent protective function against glutamate-induced neuronal injury presumably through its function in regulation of intracellular free calcium level, [Ca2+]i. In this communication, weExpand
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Molecular cloning, expression, purification, and characterization of shorter forms of human glutamic decarboxylase 67 in an E. coli expression system.
Previously, we reported the presence of truncated form of human brain l-glutamic decarboxylase 65 (tGAD65) in vivo as well as in vitro and found that tGAD65 was more active than the full-length GAD65Expand
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Identification and functional analysis of truncated human glutamic acid decarboxylase 65.
Human brain glutamate decarboxylase 65 (hGAD65) was found to exist as full-length and truncated forms when the glutathione S-transferase-tagged hGAD65 fusion protein was subjected to factor XaExpand
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A validated multi-agent simulation test bed to evaluate congestion pricing policies on population segments by time-of-day in New York City
Emerging transportation technologies differ from other engineering innovations because they require careful testing and evaluation between prototyping and deployment to avoid high public costs andExpand
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  • Open Access
Identification and Functional Analysis of Truncated Human Glutamic Acid Decarboxylase 65
Human brain glutamate decarboxylase 65 (hGAD65) was found to exist as full-length and truncated forms when the glutathione S-transferase-tagged hGAD65 fusion protein was subjected to factor XaExpand
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Effect of apocalmodulin on recombinant human brain glutamic acid decarboxylase
  • H. Jin, Di Sha, +4 authors J. Wu
  • Medicine, Chemistry
  • Journal of neurochemistry
  • 1 February 2005
In this work, we report that the recombinant glutathione S‐transferase (GST)‐human l‐glutamic acid decarboxylase (HGAD) isoforms, 65‐kDa l‐glutamic acid decarboxylase (GAD) (GST‐HGAD65) fusionExpand
  • 3
Effect of taurine on regulation of GABA and acetylcholine biosynthesis.
Taurine is one of the most abundant amino acids in mammals1 and is known to be involved in many important physiological functions, e.g.,as a trophic factor in the development of CNS2, maintaining theExpand
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The Impact of Countdown Clocks on Subway Ridership in New York City
Protecting the passengers' safety and increasing ridership are two never ending pursuits of public transit agencies. One of the proposed methods to achieve both goals for subway service is toExpand
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  • Open Access