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INTRODUCTION The challenges of rural general practice have given rise to a separate rural training stream and a separate rural professional body. The differences are characterised by the nature of the work undertaken by rural GPs and reflected in the continuing medical education topic choices made when surveyed. METHODS In 2001 a survey was designed and(More)
BACKGROUND The TP53 pathway, in which TP53 and its negative regulator MDM2 are the central elements, has an important role in carcinogenesis, particularly in BRCA1- and BRCA2-mediated carcinogenesis. A single nucleotide polymorphism (SNP) in the promoter region of MDM2 (309T>G, rs2279744) and a coding SNP of TP53 (Arg72Pro, rs1042522) have been shown to be(More)
BACKGROUND The differentiation between malignant mesothelioma and adenocarcinoma based on morphology alone can be a diagnostic challenge. The majority of the available antibodies recognize molecules expressed by adenocarcinoma whereas to the authors' knowledge specific markers for mesothelial cells are lacking. Calretinin, a calcium-binding protein, has(More)
BACKGROUND Microsatellite instability is a hallmark of mismatch repair deficiency in hereditary nonpolyposis colorectal cancer and results from mutations in the mismatch repair genes MLH1 or MSH2 or from gene inactivation associated with DNA methylation. The Bethesda guidelines were established to identify patients with colorectal cancer who should be(More)
BACKGROUND In this study we aimed to evaluate the role of a SNP in intron 1 of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers. METHODS We have genotyped rs744154 in 9408 BRCA1 and 5632 BRCA2 mutation(More)
A survey of the children at the Robarts School for the Deaf was performed in order to determine the etiology of hearing loss, the reading ability as related to the degree of hearing loss, and the incidence of middle ear disease. The largest category for etiology was idiopathic at 31%, followed by hereditary at 22.5%, and maternal rubella at 19%. The(More)
Estimates of the colon cancer burden associated with hereditary nonpolyposis colorectal cancer (HNPCC) vary from less than 1 % to more than 5 %. Amsterdam criteria fulfilled within a kindred (classic Amsterdam and Amsterdam II criteria) are widely used to identify patients prone to HNPCC. The present study was initiated to assess the frequency of the(More)
BACKGROUND Angiofibroblastoma of the skin is a recently described benign tumor with fibroblastic differentiation. The tumor is composed of stellate and spindle fibroblasts embedded in a fibromyxoid and fibrous matrix that contains numerous capillary-sized blood vessels. METHODS All cases of fibromyxoid tumors of the skin from the files of two(More)
  • Journalbeiträge Adam, R Karam, +126 authors Ghadimi M Dango
  • 2016
(2015) [Gastrointestinal stromal tumours (GIST)-development in pathology, surgery and medical therapy. (2015) HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. (2015) Reduced toxicity in the treatment of locally advanced rectal cancer: a comparison of volumetric modulated arc therapy and 3D conformal radiotherapy.(More)
BACKGROUND Learning needs analyses are often undertaken to plan continuing education programs. They usually use questionnaires that have shortcomings regarding validity, relevance, breadth and detail. We tested a questionnaire using four questioning strategies to approximately 1762 general practitioners. METHOD Our questionnaire listing 104 topics asked(More)