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Deimination refers to conversion of protein-bound arginine into citrulline. An mRNA carrier, RNA binding export factor (REF), present on mitochondria undergoes loss of deimination with impaired ATP5b mRNA transport in ND4 mice (model of multiple sclerosis) compared with the controls. We present evidence of (1) reduced ATP5b mRNA binding strength of(More)
Progressive loss of visual function frequently accompanies demyelinating diseases such as multiple sclerosis (MS) and is hypothesized to be the result of damage to the axons and soma of neurons. Here, we show that dendritic impairment is also involved in these diseases. Deimination, a posttranslational modification, was reduced in the retinal ganglion cell(More)
Multiple sclerosis (MS) is an autoimmune, inflammatory, neurodegenerative, demyelinating disease of the central nervous system, predominantly involving myelinated neurons of the brain, spinal cord, and optic nerve. Optic neuritis is frequently associated with MS and often precedes other neurologic deficits associated with MS. A large number of patients(More)
of a dissertation at the University of Miami. Dissertation supervised by Associate Professor Sanjoy K. Bhattacharya No. of pages in text. (94) Deimination refers to conversion of protein-bound arginine into citrulline. In contrast to global hyper-deimination in the brain and eyes, we have found local hypo-deimination in the retinal ganglion cell layer of(More)
PURPOSE To evaluate the ND4 transgenic mouse model of multiple sclerosis using noninvasive methods. METHODS Assessment of neurologic/behavioral abnormalities was made using pattern electroretinogram (PERG), magnetic resonance imaging (MRI), optic coherence tomography (OCT), and end point histologic analysis. RESULTS Electrophysiologic (PERG) recordings(More)
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