Dharmesh Chandra Sharma

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With around 7,500 β-thalassemia (β-thal) births in India annually, preventive measures such as pre marital counseling and prenatal diagnosis are needed to decrease the incidence of the disease in the country. The predominant mutant alleles vary from the Middle East through India to Sri Lanka, as well as in different regions within a state in India. In the(More)
Aim: This study was aimed to review and establish the practice of exchange transfusion (ET) with whole blood reconstituted (WBR) in hemolytic disease of newborn (HDN). Objectives: To observe fall in indirect serum bilirubin, correction of anemia and comparison with related studies. Background: Hemolytic disease of the Newborn is characterized by presence of(More)
PURPOSE OF STUDY Study was aimed to observe benefits of transfusion of neocytes/pooled neocytes over packed RBCs by super transfusion regimen in β-thalassemic patients and its comparison with related studies. MATERIALS AND METHODS Twelve cases were selected and were equally divided into control and study group in which packed RBCs and neocytes were(More)
This study was aimed to review and establish the practice of exchange transfusion (ET) with reconstituted blood in neonates and to observe fall of bilirubin and its comparison with related studies. Twenty-five neonates diagnosed as hemolytic disease of newborn (HDN) were selected for this study, in which exchange transfusion was carried out as one of the(More)
Primary thyroid lymphoma is a very rare disease. It presents with rapidly growing mass in elderly patients. In this report we present a case of primary lymphoma of the thyroid gland in a 55 year old male. Fine Needle Aspiration Cytology (FNAC) was used as the first line of investigation in the diagnosis. Prognosis of thyroid lymphoma is excellent and(More)
Introduction: Progesterone and Estrogen are the chief pregnancy hormones. Their levels increase during pregnancy to aid successful maintenance of pregnancy, which depends on maternal tolerance of the fetal semi allograft. Aim: To determine levels of progesterone and 17β-estradiol, at different trimesters during normal pregnancy and the puerperium, which may(More)
BACKGROUND β thalassemia results in an increase in the α to non-α chain ratio. Iron released from unpaired α chains in RBCs and that ensuing from regular transfusions is the major cause of cellular damage. The use of iron chelators to counter the iron overload is accompanied by side-effects. The extent of iron toxicity could vary from one patient to another(More)
Thalassemia major is characterized by anemia, iron overload and cellular damage. The severity of symptoms correlates with the alpha/non-alpha globin imbalance and is proportional to the magnitude of alpha chain excess. Alpha hemoglobin stabilizing protein (AHSP), the erythroid specific alpha globin chaperone, stabilizes free alpha chains, and prevents the(More)
Among a total of 29 blood group systems and over 600 different blood group antigens discovered so far, ABO and Rhesus are the most important blood group systems. The most significance rhesus antigen is Rh-D because of its immunogenicity. The sound knowledge of ABO and Rh-D antigens and its distribution in population is essential for the effective management(More)
Background: The thalassemia syndromes are a heterogeneous group of inherited disorders caused by genetic lesions leading to decreased synthesis of one or more of the globin subunits. The β-thalassemia major is the most severe form and the affected children are dependent on regular blood transfusions for survival. One of the major complications in(More)