Dhanjoo N. Ghista

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OBJECTIVE Our aim was to characterize autonomic dysfunction in patients with irritable bowel syndrome (IBS) using heart rate variability (HRV) studies. METHODS EKG signals were obtained from 35 patients (mean age, 39.1 +/- 9.5 yr, M:F ratio = 2.9:1) and 18 healthy controls (mean age, 38.2 +/- 6.5 yr, M:F ratio = 2:1) in supine, standing, and(More)
Geometric remodeling of the left ventricle (LV) after myocardial infarction is associated with changes in myocardial wall stress. The objective of this study was to determine the regional curvatures and wall stress based on three-dimensional (3-D) reconstructions of the LV using MRI. Ten patients with ischemic dilated cardiomyopathy (IDCM) and 10 normal(More)
Surgical ventricular restoration (SVR) was designed to treat patients with aneurysms or large akinetic walls and dilated ventricles. Yet, crucial aspects essential to the efficacy of this procedure like optimal shape and size of the left ventricle (LV) are still debatable. The objective of this study is to quantify the efficacy of SVR based on LV regional(More)
BACKGROUND Description of the heart as a pump has been dominated by models based on elastance and compliance. Here, we are presenting a somewhat new concept of time-varying passive and active elastance. The mathematical basis of time-varying elastance of the ventricle is presented. We have defined elastance in terms of the relationship between ventricular(More)
We have recently developed a novel design for coronary arterial bypass surgical grafting, consisting of coupled sequential side-to-side and end-to-side anastomoses. This design has been shown to have beneficial blood flow patterns and wall shear stress distributions which may improve the patency of the CABG, as compared to the conventional end-to-side(More)
Intuitional practice (i.p.), the Ananda Marga system of meditation, is a scientific mediative technique in which the subject concentrates on a particular gland and mentally incantates a 2-syllable ‘mantra’ synchronous with his breathing, the glandular site of concentration as well as the mantra are specific for a subject. The physiological responses of(More)
In this paper, coronary arterial bypass grafting hemodynamics and anastomosis designs are reviewed. The paper specifically addresses the biomechanical factors for enhancement of the patency of coronary artery bypass grafts (CABGs). Stenosis of distal anastomosis, caused by thrombosis and intimal hyperplasia (IH), is the major cause of failure of CABGs.(More)
BACKGROUND Coronary artery bypass grafting surgery is an effective treatment modality for patients with severe coronary artery disease. The conduits used during the surgery include both the arterial and venous conduits. Long- term graft patency rate for the internal mammary arterial graft is superior, but the same is not true for the saphenous vein grafts.(More)
In this paper, the hemodynamics in a three-dimensional out-of-plane sequential bypass graft model is first investigated. Based on the advantageous flow characteristics observed within the side-to-side (STS) anastomosis in the sequential bypass graft simulation, a new CABG coupled-sequential anastomosis configuration is designed, entailing coupled STS and(More)