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Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43.

• David E. Gutstein, Gregory E. Morley, +6 authors Glenn I. Fishman
• Circulation research
• 2001

Cardiac arrhythmia is a common and often lethal manifestation of many forms of heart disease. Gap junction remodeling has been postulated to contribute to the increased propensity for… (More)

AV nodal function during atrial fibrillation: the role of electrotonic modulation of propagation.

• Frits L Meijler, José Jalife, Jacques Beaumont, Dhananjay Vaidya
• Journal of cardiovascular electrophysiology
• 1996

The irregular ventricular rhythm that accompanies atrial fibrillation (AF) has been explained in terms of concealed conduction within the AV node (AVN). However, the cellular basis of concealed… (More)

Reentry and fibrillation in the mouse heart. A challenge to the critical mass hypothesis.

• Dhananjay Vaidya, Gregory E. Morley, Faramarz H. Samie, José Jalife
• Circulation research
• 1999

The idea that fibrillation is only possible in hearts exceeding a critical size was introduced by W. Garrey >80 years ago and has since been generally accepted. In ventricular tissue, this critical… (More)

Heterogeneous expression of Gap junction channels in the heart leads to conduction defects and ventricular dysfunction.

• David E. Gutstein, Gregory E. Morley, +4 authors Glenn I. Fishman
• Circulation
• 2001

BACKGROUND - Heterogeneous remodeling of gap junctions is observed in many forms of heart disease. The consequent loss of synchronous ventricular activation has been hypothesized to result in… (More)

Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development.

• Dhananjay Vaidya, Houman S. Tamaddon, +4 authors José Jalife
• Circulation research
• 2001

Connexin43 (Cx43) is the principal connexin isoform in the mouse ventricle, where it is thought to provide electrical coupling between cells. Knocking out this gene results in anatomic malformations… (More)

Sex-steroid hormones and electrocardiographic QT-interval duration: findings from the third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis.

• Yiyi Zhang, Pamela Ouyang, +6 authors Eliseo Guallar
• American journal of epidemiology
• 2011

The association between physiologic levels of sex hormones and QT-interval duration in humans was evaluated using data from 727 men enrolled in the Third National Health and Nutrition Examination… (More)

Conditional lineage ablation to model human diseases.

• Peng Ng Ang Noi Lee, G. Morley, +7 authors Glenn I. Fishman
• Proceedings of the National Academy of Sciences…
• 1998

Cell loss contributes to the pathogenesis of many inherited and acquired human diseases. We have developed a system to conditionally ablate cells of any lineage and developmental stage in the mouse… (More)

Impact of a community-based multiple risk factor intervention on cardiovascular risk in black families with a history of premature coronary disease.

• Diane M. Becker, Lisa R Yanek, +6 authors Lewis C. Becker
• Circulation
• 2005

BACKGROUND Black subjects with a family history of premature coronary heart disease (CHD) have a marked excess risk, yet barriers prevent effective risk reduction. We tested a community-based… (More)

Late Systolic Central Hypertension as a Predictor of Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis

• Julio A. Chirinos, Patrick Segers, +8 authors David R. Jacobs
• Journal of the American Heart Association
• 2015

BACKGROUND Experimental studies demonstrate that high aortic pressure in late systole relative to early systole causes greater myocardial remodeling and dysfunction, for any given absolute peak… (More)

High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system.

• Houman S. Tamaddon, Dhananjay Vaidya, Alexander M. Simon, David L. Paul, José Jalife, Gregory E. Morley
• Circulation research
• 2000

Connexin40 (Cx40) is a major gap junction protein that is expressed in the His-Purkinje system and thought to be a critical determinant of cell-to-cell communication and conduction of electrical… (More)

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