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Without a complete published description of interventions, clinicians and patients cannot reliably implement interventions that are shown to be useful, and other researchers cannot replicate or build on research findings. The quality of description of interventions in publications, however, is remarkably poor. To improve the completeness of reporting, and(More)
The aim of this prospective study was to assess the repeatability of measurement of fetal nuchal translucency thickness at 10-14 weeks' gestation. The nuchal translucency was measured by two of four operators in 200 pregnant women attending the Harris Birthright Research Centre for Fetal Medicine at 10-14 weeks' gestation. To assess repeatability of(More)
BACKGROUND The design of randomised controlled trials (RCTs) should incorporate characteristics (such as concealment of randomised allocation and blinding of participants and personnel) that avoid biases resulting from lack of comparability of the intervention and control groups. Empirical evidence suggests that the absence of such characteristics leads to(More)
BACKGROUND There is controversy over whether patients presenting with a primary attack of acute diverticulitis at a younger age are more prone to complications and recurrence than older patients. METHODS A review, including postal questionnaires, was undertaken of 234 patients who had a primary episode of acute diverticulitis. The diagnosis was confirmed(More)
INTERGROWTH-21(st) is a multicentre, multiethnic, population-based project, being conducted in eight geographical areas (Brazil, China, India, Italy, Kenya, Oman, UK and USA), with technical support from four global specialised units, to study growth, health and nutrition from early pregnancy to infancy. It aims to produce prescriptive growth standards,(More)
OBJECTIVE To assess the risk for obstetric anal sphincter lacerations in relation to maternal obesity among primiparous women in Sweden. DESIGN A population-based study. SETTING Sweden. POPULATION All women with vaginal delivery and singleton pregnancy in Sweden in the years 2003-2008 (n = 210,678). METHODS The Medical Birth Registry, the National(More)
High response rates have been reported with hepatic intra-arterial infusions of floxuridine in patients having colorectal carcinoma metastatic to the liver. The major toxicity of this therapy has been described as "chemical hepatitis." In a randomized trial of intravenous v intra-arterial floxuridine, we observed that all 35 patients receiving(More)
MR was performed on six patients clinically diagnosed as having neurofibromatosis. Owing to its multiplanar capability, MR greatly helped determine the extent of visual pathway disease. We attempted to find specific optimal pulse sequences for evaluating the prechiasmatic, chiasmatic, and retrochiasmatic visual system at 0.35 T. Using spin-echo techniques,(More)
OBJECTIVE To assess intra- and interobserver variability of fetal biometry measurements throughout pregnancy. METHODS A total of 175 scans (of 140 fetuses) were prospectively performed at 14-41 weeks of gestation ensuring an even distribution throughout gestation. From among three experienced sonographers, a pair of observers independently acquired a(More)
OBJECTIVES To assess the effect of coffee and tea consumption on symptoms of urinary incontinence. DESIGN Population-based study. SETTING The Swedish Twin Register. POPULATION In 2005, all twins born between 1959 and 1985 in Sweden (n = 42,852) were invited to participate in a web-based survey to screen for common complex diseases and common(More)