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PURPOSE Studies have suggested that the medial dorsal nucleus of the thalamus plays a role in the behavioral expression of limbic seizures, but it is unclear whether this region is a key component for the primary seizure circuitry or a path for seizure spread from one region to another. This study was undertaken to determine the potential role of this(More)
Occupational exposure and experimental intoxication of acrylamide (ACR) can produce skeletal muscle weakness and ataxia. In this study, we tested whether ACR would affect cerebellar function through the regulation of gamma-aminobutyric acid (GABA) and glial fibrillary acidic protein (GFAP) expression in cerebellum. Weaning male Sprague-Dawley rats were(More)
INTRODUCTION The midline thalamic nuclei are an important component of limbic seizures. Although the anatomic connections and excitatory influences of the midline thalamus are well known, its physiological role in limbic seizures is unclear. We examined the role of the midline thalamus on two circuits that are involved in limbic seizures: (a) the(More)
PURPOSE The midline thalamus is an important component of the circuitry in limbic seizures, but it is unclear how synaptic modulation of the thalamus affects that circuitry. In this study, we wished to understand how synaptic modulation of the thalamus can affect interregional signaling and seizure spread in the limbic network. METHODS We examined the(More)
OBJECTIVE To study the poisonous effect of manganese on the postnatal development of dopaminergic neurons of nigra substance in rat brain. METHODS Morris Water Maze was carried out to examine the muscle motor ability of the rat. Fluorometry was used to determine the dopamine levels of caudate nucleus. Immunochemistry combined with digital imagine analysis(More)
The toxicity of manganese exposure on the postnatal development of brain in mice was investigated. Muscle motor ability was examined by Morris Water Maze, spontaneous action by Open Field Maze, neuro-anxiety by Elevated Plus Arms Maze. Lipid peroxides (LPO) level and superoxide dismutase (SOD) activity of brain was detected by neurobiochemical assay; glial(More)
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