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BACKGROUND Treatment of early-stage osteonecrosis of the femoral head (ONFH) with autologous implantation of iliac crest bone marrow-derived mononuclear cells, which contain tens of thousands of bone marrow mesenchymal stem cells (BMMSCs), recently achieved a promising outcome. METHODS One hundred patients with early-stage ONFH were recruited and randomly(More)
In this paper, an improved Prewitt algorithm for edge detection is proposed for the reason that the traditional Prewitt edge detection algorithm is sensitive to the noise. The traditional Prewitt edge detection operator only has two templates with horizontal and vertical directions. While the edge is in a plurality of directions, so operator with eight(More)
BACKGROUND Various head-preserving procedures have been used for young patients with osteonecrosis of the femoral head (ONFH) to avert the need for THA. However, none of these techniques are accepted universally because of the technical difficulties, complications, or mixed results that often are difficult to reproduce. QUESTIONS/PURPOSES We describe a(More)
The aim of this report is to present our experience on the use of the digital subtraction angiography (DSA) in selection of the vascularized greater trochanter bone grafting for the treatment of the osteonecrosis of femoral head (ONFH) in early stages. Between January 2005 and June 2007, DSA was used to evaluate the blood perfusion of the early stages ONFH(More)
OBJECTIVE To evaluate the clinical effect of treatment of osteonecrosis of the femoral head (ONFH) by minimally invasive vascularized bone grafting. METHODS 232 ONFH patients (232 hips), 146 males and 86 females, aged 39.8 (22 - 55), 114 being at the Ficat and Arlet stage II, 96 at stage III, and 22 at stage IV, were treated with minimally invasive(More)
Osteoclasts together with osteoblasts play pivotal roles in bone remodeling. The unique function and ability of osteoclasts to resorb bone makes them critical in both normal bone homeostasis and pathologic bone diseases such as osteoporosis and rheumatoid arthritis. Thus, new compounds that may inhibit osteoclastogenesis and osteoclast function may be of(More)
OBJECTIVE To explore the changes and its significance of the expression of vascular endothelial growth factor (VEGF) protein and messenger RNA in the Beagle dogs femoral head during the repairing process of the osteonecrosis of femoral head (ONFH) under different stress force stimulations. METHODS Twenty-four Beagle dogs were selected to establish the(More)
As a new generation of medical metallic material, magnesium (Mg) and its alloys with or without surface coating have attracted a great deal of attention due to its biodegradability and potential for avoiding a removal operation after the implant has fulfilled its function for surgical fixation of injured musculoskeletal tissues. Although a few clinical(More)
Osteonecrosis of the femoral head is a progressive disease. Without operative intervention, it most often results in collapse and deterioration of the joint. Many joint-preserving surgeries have been implemented, but no uniform treatment exists. The authors report a modified technique of tantalum rod implantation combined with vascularized iliac grafting(More)
OBJECTIVES The aim of this work was to identify the uridine glucuronosyltransferase (UGT) isoforms involved in the metabolism of the broad-spectrum antiviral drug arbidol. METHODS A human liver microsome (HLM) incubation system was employed to catalyse the formation of arbidol glucuronide. The glucuronidation activity of commercially recombinant UGT(More)