Devansh R. Gupta

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A new prenylated flavanone glycoside, nirurin, has been isolated from Phyllanthus nirurii. On the basis of chemical and spectral studies, its structure is proposed as 5,6,7,4'-tetrahydroxy-8-(3-methylbut-2-enyl) flavanone-5-O-rutinoside (1). The aglycone, also a new flavanone, has been characterized as 5,6,7,4'-tetrahydroxy-8-(3-methylbut-2-enyl) flavanone,(More)
The impact of drug loading and distribution on higher order structure and physical stability of an interchain cysteine-based antibody drug conjugate (ADC) has been studied. An IgG1 mAb was conjugated with a cytotoxic auristatin payload following the reduction of interchain disulfides. The 2-D LC-MS analysis shows that there is a preference for certain(More)
  • D Gupta
  • 1966
In order to study the hydrolysis, enzymatic or chemical, of the plasma and urinary steroid glucuronides, as well as the biosynthesis, the isolation of the individual 17-oxosteroids is an absolute necessity. Schneider and Lewbart (1959) employed counter-current distribution techniques to isolate several steroid glucuronides. Androsterone glucuronide was(More)
We investigate computationally the dynamical transitions in Trp-cage miniprotein powders, at three levels of hydration: 0.04, 0.26 and 0.4 g water/g protein. We identify two distinct temperatures where transitions in protein dynamics occur. Thermal motions are harmonic and independent of hydration level below Tlow ≈ 160 K, above which all powders exhibit(More)
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