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UNLABELLED BACK GROUND AND THE PURPOSE OF STUDY: Many drug substances and variety of naturally occurring dietary or herbal components are capable of interaction with the CYP enzyme system. The aim of the study was to investigate the effect of pomegranate juice pretreatment on the bioavailability of buspirone in rabbits. METHODS White New Zealand rabbits(More)
BACKGROUND AND THE PURPOSE OF THE STUDY Many drug substances along with a variety of naturally occurring dietary or herbal components interact with the CYP enzyme system. The present study was aimed to investigate the effect of pomegranate juice pre-treatment on the transport of carbamazepine across the rat intestine. METHODS The transport of(More)
P-Glycoprotein (P-gp), the most extensively studied ATP-binding cassette transporter, functions as a biological barrier by extruding toxic substances and xenobiotics out of cells. Drug efflux pumps such as P-gp play a functional role in determining the pharmacokinetics of drugs administered by oral and parenteral routes. Determining the activity of drug(More)
Objective of this work was to develop and validate a method for detection of Pioglitazone hydrochloride (Thiazolidinedione, very potent and effective anti diabetic agent) in tablet dosage forms by High performance liquid chromatography. The HPLC system consisting Waters analytical C18 column (46×250 mm), detected at 245 nm, sensitivity was 0.001 AUFS and(More)
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