Detlef Zillikens

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Pemphigoid diseases are a group of well defined autoimmune disorders that are characterised by autoantibodies against structural proteins of the dermal-epidermal junction and, clinically, by tense… (More)

The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators.

Lawrence S. Chan, Amal Ahmed, +23 authors John J. Zone
Archives of dermatology
2002

OBJECTIVE We aimed to develop consensus-based recommendations for streamlining medical communication among various health care professionals, to improve accuracy of diagnosis and treatment, and to… (More)

Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus.

D F Murrell, S. Dick, +27 authors Victoria P. Werth
Journal of the American Academy of Dermatology
2008

Our scientific knowledge of pemphigus has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a… (More)

Modern diagnosis of autoimmune blistering skin diseases.

Enno Schmidt, Detlef Zillikens
Autoimmunity reviews
2010

The diagnostic gold standard of autoimmune bullous diseases is the detection of autoantibodies in skin or mucous membranes by direct immunofluorescence microscopy of a perilesional biopsy. The… (More)

Prospective analysis of the incidence of autoimmune bullous disorders in Lower Franconia, Germany.

Franziska Bertram, Eva-B. Bröcker, Detlef Zillikens, Enno Schmidt
Journal der Deutschen Dermatologischen…
2009

BACKGROUND Only limited epidemiologic data are available on autoimmune bullous diseases. Improved diagnostic tools should have led to an increased incidence. To test this hypothesis, all patients… (More)

Risk factors for lethal outcome in patients with bullous pemphigoid: low serum albumin level, high dosage of glucocorticosteroids, and old age.

B. Rzany, Karin Partscht, +17 authors Gerald Messer
Archives of dermatology
2002

BACKGROUND Although bullous pemphigoid (BP) is the most frequent autoimmune bullous disease and is associated with a considerable case-fatality rate, little is known about factors that influence its… (More)

Inhibition of Rho A activity causes pemphigus skin blistering

Jens Waschke, Volker Spindler, Paola Bruggeman, Detlef Zillikens, Gudula Schmidt, Detlev Drenckhahn
The Journal of cell biology
2006

The autoimmune blistering skin diseases pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are mainly caused by autoantibodies against desmosomal cadherins. In this study, we provide evidence that… (More)

Rituximab for treatment-refractory pemphigus and pemphigoid: a case series of 17 patients.

Michael Kasperkiewicz, Iakov Shimanovich, Ralf J Ludwig, Christian Rose, Detlef Zillikens, Enno Schmidt
Journal of the American Academy of Dermatology
2011

BACKGROUND Rituximab has been increasingly used in autoimmune blistering dermatoses, mainly in pemphigus. However, only a few larger case series are available on this subject and information on the… (More)

PI3Kβ plays a critical role in neutrophil activation by immune complexes.

Suhasini Kulkarni, C Sitaru, +19 authors Phillip T. Hawkins
Science signaling
2011

Neutrophils are activated by immunoglobulin G (IgG)-containing immune complexes through receptors that recognize the Fc portion of IgG (FcγRs). Here, we used genetic and pharmacological approaches to… (More)

Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen.

C Sitaru, Sidonia Mihai, +7 authors Detlef Zillikens
The Journal of clinical investigation
2005

Epidermolysis bullosa acquisita (EBA) is a subepidermal blistering disorder associated with tissue-bound and circulating autoantibodies specific to type VII collagen, a major constituent of the… (More)

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