Detlef Snakenborg

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Taking the next step from individual functional components to higher integrated devices, we present a feasibility study of a lab-on-a-chip system with five different components monolithically integrated on one substrate. These five components represent three main domains of microchip technology: optics, fluidics and electronics. In particular, this device(More)
Here, we describe a multi-parametric study of DNA hybridization to probes with 20-70% G + C content. Probes were designed towards 71 different sites/mutations in the phenylalanine hydroxylase gene. Seven probe lengths, three spacer lengths and six stringencies were systematically varied. The three spacer lengths were obtained by placing the gene-specific(More)
In this paper a method is presented for creating 'interconnection blocks' that are re-usable and provide multiple, aligned and planar microfluidic interconnections. Interconnection blocks made from polydimethylsiloxane allow rapid testing of microfluidic chips and unobstructed microfluidic observation. The interconnection block method is scalable, flexible(More)
In this paper we present a modular lab-on-a-chip system for integrated sample pre-treatment (PT) by magnetophoresis and DNA amplification by polymerase chain reaction (PCR). It consists of a polymer-based microfluidic chip mounted on a custom made thermocycler (Figure 1) and includes a simple and efficient method for switching the liquid flow between the PT(More)
In this work, we present a non-permanent method to connect microfluidic devices. The approach uses short flexible tubes that are plugged into bottom-flat holes and ensure fast and reliable interconnections. The small available dimensions allow the tube to be directly attached to the side of planar microchips. A theoretical model to estimate the maximum(More)
The field related to the development of microfluidic systems performing biochemical analysis is continuously growing. Careful packaging of microsystems is vital to ensure efficient work of the device, especially at the interface between the system and the environment, where fluidic electrical and optical interconnections must be provided in a reliable(More)
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