Detlef Snakenborg

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Taking the next step from individual functional components to higher integrated devices, we present a feasibility study of a lab-on-a-chip system with five different components monolithically integrated on one substrate. These five components represent three main domains of microchip technology: optics, fluidics and electronics. In particular, this device(More)
Here, we describe a multi-parametric study of DNA hybridization to probes with 20-70% G + C content. Probes were designed towards 71 different sites/mutations in the phenylalanine hydroxylase gene. Seven probe lengths, three spacer lengths and six stringencies were systematically varied. The three spacer lengths were obtained by placing the gene-specific(More)
In this work, we present a non-permanent method to connect microfluidic devices. The approach uses short flexible tubes that are plugged into bottom-flat holes and ensure fast and reliable interconnections. The small available dimensions allow the tube to be directly attached to the side of planar microchips. A theoretical model to estimate the maximum(More)
In this paper we present a modular lab-on-a-chip system for integrated sample pre-treatment (PT) by magnetophoresis and DNA amplification by polymerase chain reaction (PCR). It consists of a polymer-based microfluidic chip mounted on a custom made thermocycler (Figure 1) and includes a simple and efficient method for switching the liquid flow between the PT(More)
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