Detlef Müller

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This review provides a framework contributing to the risk assessment of acrylamide in food. It is based on the outcome of the ILSI Europe FOSIE process, a risk assessment framework for chemicals in foods and adds to the overall framework by focusing especially on exposure assessment and internal dose assessment of acrylamide in food. Since the finding that(More)
We present an inversion algorithm for the retrieval of particle size distribution parameters, i.e., mean (effective) radius, number, surface area, and volume concentration, and complex refractive index from multiwavelength lidar data. In contrast to the classical Tikhonov method, which accepts only that solution for which the discrepancy reaches its global(More)
A.G. Renwick, S.M. Barlow, I. Hertz-Picciotto, A.R. Boobis, E. Dybing, L. Edler, G. Eisenbrand, J.B. Greig, J. Kleiner*, J. Lambe, D.J.G. Müller, M.R. Smith, A. Tritscher, S. Tuijtelaars, P.A. van den Brandt, R. Walker, R. Kroesp,y University of Southampton, Clinical Pharmacology Group, School of Medicine, Biomedical Sciences Building, Bassett Crescent(More)
Albert Ansmann, Jens Bösenberg, Anatoli Chaikovsky, Adolfo Comerón, Sabine Eckhardt, Ronald Eixmann, Volker Freudenthaler, Paul Ginoux, Leonce Komguem, Holger Linné, Miguel Ángel López Márquez, Volker Matthias, Ina Mattis, Valentin Mitev, Detlef Müller, Svetlana Music, Slobodan Nickovic, Jacques Pelon, Laurent Sauvage, Piotr Sobolewsky, Manoj K. Srivastava,(More)
Exposure assessment is one of the key parts of the risk assessment process. Only intake of toxicologically significant amounts can lead to adverse health effects even for a relatively toxic substance. In the case of chemicals in foods this is based on three major aspects: (i) how to determine quantitatively the presence of a chemical in individual foods and(More)
We report on the feasibility of deriving microphysical parameters of bimodal particle size distributions from Mie-Raman lidar based on a triple Nd:YAG laser. Such an instrument provides backscatter coefficients at 355, 532, and 1064 nm and extinction coefficients at 355 and 532 nm. The inversion method employed is Tikhonov's inversion with regularization.(More)
A sensitivity study with an inversion scheme that permits one to retrieve physical parameters of tropospheric particle size distributions, e.g., effective radius, volume, surface-area, and number concentrations, as well as the mean complex refractive index from backscatter and extinction coefficients at multiple wavelengths is presented. The optical data(More)
A method is proposed that permits one to retrieve physical parameters of tropospheric particle size distributions, e.g., effective radius, volume, surface-area, and number concentrations, as well as the mean complex refractive index on a routine basis from backscatter and extinction coefficients at multiple wavelengths. The optical data in terms of vertical(More)
BACKGROUND Significant subgroups in most European populations have intakes below nationally recommended levels for several vitamins, minerals and trace elements, placing individuals at risk of suboptimal intake of important vitamins and minerals. The voluntary addition of micronutrients to the appropriate foods may help address the risks associated with low(More)
Recombinant DNA techniques are capable of introducing genetic changes into food organisms that are more predictable than those introduced through conventional breeding techniques. This review discusses whether the consumption of DNA in approved novel foods and novel food ingredients derived from genetically modified organisms (GMOs) can be regarded as being(More)