Detlef Klaus Bartsch

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An international initiative is developing a scientifically rigorous approach to evaluate the potential risks to nontarget arthropods (NTAs) posed by insect-resistant, genetically modified (IRGM) crops. It adapts the tiered approach to risk assessment that is used internationally within regulatory toxicology and environmental sciences. The approach focuses(More)
BACKGROUND Although as many as 10% of pancreatic cancer cases may have an inherited component, familial pancreatic cancer has not been linked to defects in any specific gene. Some studies have shown that families with germline mutations in the breast cancer susceptibility gene BRCA2 have an increased risk of breast and ovarian cancers, as well as a modestly(More)
a Department of General Surgery, University of Verona, Verona , Italy; b Department of Surgery, Philipps University, Marburg , Germany; c Department of Endocrinology, University Hospital, Uppsala , Sweden; d Department of Pathology, Technical University of Munich, Munich , Germany; e Faculdade de Medicina do Porto & IPATIMUP, Porto , Portugal; f Instituto(More)
OBJECTIVE Familial pancreatic cancer (FPC) accounts for approximately 3% of all pancreatic cancer (PC) cases. It has been suggested that high-risk individuals (HRIs) should be offered a screening programme. AIM To evaluate the diagnostic yield of a prospective screening programme in HRIs from families with FPC over a period of 5 years. METHODS HRIs of(More)
BACKGROUND The management of pancreaticoduodenal endocrine tumors (PETs) remains controversial in multiple endocrine neoplasia type 1 (MEN 1). METHODS Twenty-one patients with MEN 1 and PETs were analyzed for outcome of surgery and surveillance with special regard to the genotype based on MEN1 gene mutation analysis. RESULTS Nine patients had(More)
BACKGROUND Screening individuals at increased risk for pancreatic cancer (PC) detects early, potentially curable, pancreatic neoplasia. OBJECTIVE To develop consortium statements on screening, surveillance and management of high-risk individuals with an inherited predisposition to PC. METHODS A 49-expert multidisciplinary international consortium met to(More)
The European corn borer, Ostrinia nubilalis (Hübner), is one of the most important insect pests in corn, Zea mays L. Transgenic corn cultivars expressing Bacillus thuringiensis (Bt) toxin provide a promising crop protection strategy against European corn borer; however, management is needed to avoid resistance development of the target pest species. The aim(More)
One of the most discussed environmental effects associated with the use of transgenic plants is the flow of genes to plants in the environment. The flow of genes may occur through pollen since it is the reproductive system that is designed for gene movement. Pollen-mediated gene escape is hard to control in mating plants. Pollen from a wind pollinator can(More)
a Department of Surgery, San Raffaele Hospital, Università Vita e Salute, Milan , Italy; b Department of Endocrine Oncology, University Hospital, Uppsala , Sweden; c Department of Pathophysiology, Division of Endocrinology, National University of Athens, Athens , Greece; d Department of Surgery, Philipps University, Marburg , Germany; e Institute of(More)
Recently, PALB2 was reported to be a new pancreatic cancer susceptibility gene as determined by exomic sequencing, as truncating PALB2 mutations were identified in 3 of 96 American patients with familial pancreatic cancer (FPC). Representing the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) and the German National(More)