Detlef Birkholz

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There has been no proven method thus far to accelerate the clearance of potentially toxic perfluorinated compounds (PFCs) in humans. PFCs are a family of commonly used synthetic compounds with many applications, including repelling oil and stains on furniture, clothing, carpets and food packaging, as well as in the manufacturing of polytetrafluoroethylene -(More)
BACKGROUND Bisphenol A (BPA) is an ubiquitous chemical contaminant that has recently been associated with adverse effects on human health. There is incomplete understanding of BPA toxicokinetics, and there are no established interventions to eliminate this compound from the human body. Using 20 study participants, this study was designed to assess the(More)
There is limited understanding of the toxicokinetics of bioaccumulated toxic elements and their methods of excretion from the human body. This study was designed to assess the concentration of various toxic elements in three body fluids: blood, urine and sweat. Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10(More)
The estrogen receptor (ER) signaling cascade is a vulnerable target of exposure to environmental xenoestrogens, like nonylphenol (NP), which are causally associated with impaired health status. However, the impact of xenoestrogens on the individual receptor isotypes (alpha, beta a, and beta b) is not well understood. The goal of these studies was to(More)
With effective antibacterial and antifungal properties, commercially used parabens are synthetic compounds widely utilized as preservatives in cosmetics, personal care products, pharmaceuticals, and as an additive in some foodstuffs. While long regarded as relatively safe and nontoxic, recent research has demonstrated xenoestrogenic properties of(More)
Evidence of fresh oil from the BP/Deepwater Horizon Mississippi Canyon-252 (MC-252) well was found in the northern Gulf of Mexico up to 1 year and 10 months after it was capped on 15 July 2010. Offshore and coastal samples collected after capping displayed ratios of biomarkers matching those of MC-252 crude oil. Pre- and post-capping samples were compared.(More)
Perfluorinated acids have received increasing scientific attention due to their widespread global distribution, environmental persistence and bioaccumulation in wildlife and humans. For perfluorohexane sulfonate (PFHxS, C(6)F(13)SO(3) (-), m/z 399), all existing human data have been generated using high-performance liquid chromatography (HPLC) and its most(More)
BACKGROUND Individual members of the phthalate family of chemical compounds are components of innumerable everyday consumer products, resulting in a high exposure scenario for some individuals and population groups. Multiple epidemiological studies have demonstrated statistically significant exposure-disease relationships involving phthalates and(More)
Perfluorinated compounds (PFCs) are man-made organofluorine chemicals manufactured and marketed for their stain-resistant properties. Polychlorinated biphenyls (PCBs) are anthropogenic organochlorine compounds previously used in various industrial and chemical applications prior to being banned in the Western world in the 1970s. Both PFCs and PCBs are(More)
Background. While perfluorinated compounds (PFCs) are a family of commonly used synthetic compounds with many applications, some PFCs remain persistent within the human body due, in part, to enterohepatic recirculation and renal tubular reabsorption. With increasing recognition of potential harm to human health associated with PFC bioaccumulation,(More)