Despo Ierodiakonou

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BACKGROUND The incidence of anaphylaxis might be increasing. Data for fatal anaphylaxis are limited because of the rarity of this outcome. OBJECTIVE We sought to document trends in anaphylaxis admissions and fatalities by age, sex, and cause in England and Wales over a 20-year period. METHODS We extracted data from national databases that record(More)
RATIONALE The evidence supporting an association between traffic-related air pollution exposure and incident childhood asthma is inconsistent and may depend on genetic factors. OBJECTIVES To identify gene-environment interaction effects on childhood asthma using genome-wide single-nucleotide polymorphism (SNP) data and air pollution exposure. Identified(More)
E-cadherins form intercellular junctions that maintain epithelial integrity. Epithelial integrity is impaired in asthma and can be restored by inhaled corticosteroids (ICSs). Our aim was to investigate the association of CDH1 gene polymorphisms (single-nucleotide polymorphisms (SNPs)) with airway remodelling, inflammation and forced expiratory volume in 1 s(More)
OBJECTIVE To determine whether feeding infants with hydrolysed formula reduces their risk of allergic or autoimmune disease. DESIGN Systematic review and meta-analysis, as part of a series of systematic reviews commissioned by the UK Food Standards Agency to inform guidelines on infant feeding. Two authors selected studies by consensus, independently(More)
BACKGROUND Although ambient air pollution has been linked to reduced lung function in healthy children, longitudinal analyses of pollution effects in asthmatic patients are lacking. OBJECTIVE We sought to investigate pollution effects in a longitudinal asthma study and effect modification by controller medications. METHODS We examined associations of(More)
Importance Timing of introduction of allergenic foods to the infant diet may influence the risk of allergic or autoimmune disease, but the evidence for this has not been comprehensively synthesized. Objective To systematically review and meta-analyze evidence that timing of allergenic food introduction during infancy influences risk of allergic or(More)
et al. Physical activity is the strongest predictor of all-cause mortality in patients with COPD: a prospective cohort study. A, et al. Patient-reported physical activity questionnaires: a systematic review of content and format. Health Qual Life Outcomes 2012; 10: 28. 7 Leidy NK. Functional status and the forward progress of merry-go-rounds: toward a(More)
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