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A novel intermembrane space–targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding
A nine-residue intermembrane-targeting signal brings the active Cys of substrate proteins into contact with Mia40 oxidase for folding and import into mitochondria.
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Signaling at the gate: Phosphorylation of the mitochondrial protein import machinery
Protein import into mitochondria is an essential process in every eukaryotic organism. While most of the components of the import machinery have been identified and are mechanistically quite wellExpand
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Glucose-induced regulation of protein import receptor Tom22 by cytosolic and mitochondria-bound kinases.
Most mitochondrial proteins are imported by the translocase of the outer mitochondrial membrane (TOM). Tom22 functions as central receptor and transfers preproteins to the import pore. Casein kinaseExpand
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From inventory to functional mechanisms
For decades, the pyruvate dehydrogenase complex in the mitochondrial matrix was considered as a rare example of how protein kinases and phosphatases can regulate important functions within thisExpand
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