Despina A Tata

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AIMS Methamphetamine is an amphetamine derivative that is abused increasingly world-wide at an alarming rate over the last decade. Pre-clinical and human studies have shown that methamphetamine is neurotoxic to brain dopamine and serotonin. Other lines of study indicate that stress enhances the vulnerability to drug abuse. The purpose of this review is to(More)
Stress is known to enhance the abuse of various drugs. Although the effects of chronic stress and the neurotoxicity of methamphetamine (METH) are influenced, in part, by hyperthermia, the role of hyperthermia in the hypothesized stress-induced enhancement of METH-induced dopamine (DA) and serotonin depletions and decreases in vesicular monoamine transporter(More)
Striking parallels exist between the neurochemical and toxic effects of stress and methamphetamine. Despite these similarities, no studies have examined how stress may promote the toxic effects of methamphetamine (METH). The current study tested the hypothesis that chronic stress enhances METH toxicity by augmenting glutamate (GLU) release and(More)
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