Desmond Kirkpatrick

Learn More
In coupling delay computation, a <i>Miller factor</i> of more than 2X may be necessary to account for active coupling capacitance when modeling the delay of deep submicron circuitry in the presence of active coupling capacitance. We propose an efficient method to estimate this factor such that the delay response of a <i>decoupling circuit model</i> can(More)
We study scaling in the context of typical block-level wiring distributions, and identify its impact on the design process. In particular, we study the implications of exponentially increasing repeater and clocked repeater counts on the algorithms and methodologies used for physical synthesis and full-chip assembly, showing that mere capacity scaling of(More)
We present the results of scaling studies in the context of typical block-level wiring distributions, and study the impact of the identified trends on the post-RTL design process. In particular, we look at the implications of exponentially increasing repeater and clocked repeater counts on the algorithms and methodologies used for logic synthesis,(More)
Maintaining signal integrity in digital systems is becoming increasingly difficult due to the rising number of analog effects seen in deep submicron design. One such effect, the signal crosstalk problem, is now a serious design concern. Signals which couple electrically may not affect system behavior because of timing or function in the digital domain. If(More)
The interactions of a series of 2-imidazolyl disulfide antitumor compounds with the thioredoxin reductase(TR)/thioredoxin (hTrx) redox system have been studied. Disulfides III-2 (n-butyl 2-mercaptoimidazolyl disulfide) and VI-2 (ethyl 2-mercaptoimidazolyl disulfide) were substrates for reduction by TR with Km values of 43 and 48 microM. Disulfides IV-2(More)
Crosstalk effect is crucial for timing analysis in very deep submicron design. In this paper, we present and compare multiple scheduling algorithms to compute switching windows for static timing analysis in presence of crosstalk noise. We also introduce an efficient technique to evaluate the worst case alignment of multiple aggressors.
To test the hypothesis that activation of the protein kinase C (PKC) epsilon isoform leads to cardiac hypertrophy without failure, we studied transgenic mice with cardiac-specific overexpression of a constitutively active mutant of the PKCepsilon isoform driven by an alpha-myosin heavy chain promoter. In transgenic mice, the protein level of PKCepsilon in(More)
Thioredoxin is a redox protein found over-expressed in some human tumors. Thioredoxin is secreted by tumor cells and stimulates cancer cell growth. Redox activity is essential for growth stimulation by thioredoxin. Cells transfected with thioredoxin cDNA show increased tumor growth and decreased apoptosis in vivo and decreased sensitivity to apoptosis(More)
Interconnect performance does not scale well into deep submicron dimensions, and the rising number of analog effects erodes the digital abstraction necessary for high levels of integration. In particular, crosstalk is an analog phenomenon of increasing relevance. To cope with the increasingly analog nature of high-performance digital system design, we(More)