Desislava Tsoneva

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Blood tests are necessary, easy-to-perform and low-cost alternatives for monitoring of oncolytic virotherapy and other biological therapies in translational research. Here we assessed three candidate proteins with the potential to be used as biomarkers in biological fluids: two glucuronidases from E. coli (GusA) and Staphylococcus sp. RLH1 (GusPlus), and(More)
Oncolytic virotherapy is safe and clinically active in solid tumors, however its efficacy in hematologic malignancies as well as in combination with checkpoint inhibitors and radiation is unexplored. To simulate advanced lymphoma, A20 cells were injected subcutaneously on bilateral flanks of BALB/c mice and treatment initiated on day 17 to only the right(More)
Herein we describe the use of the vaccinia virus strain GLV-1h68 as a theragnostic agent in cancer models. To date, GLV-1h68 has been used successfully in more than 50 xenograft tumor models. The recombinant vaccinia virus strain has been equipped with heterologous expression cassettes for a luciferase-fluorescent protein fusion gene, bacterial(More)
The authors reveal the formation of free radicals in biologic objects stressing upon the influence of Propofol (Diprivan; Zeneca; London, UK) as an intravenous agent during laparoscopic cholecystectomy (LCCE) lipid peroxidation. Some LCCE surgical details help this process resulting in free radical synthesis. The antioxidant effect of Propofol in vitro(More)
BACKGROUND Abdominal compartment syndrome (ACS) manifests with increase of intra abdominal pressure (IAP) and organ dysfunction resulting in multiple organ failure. ACS presents with respiratory failure, hemodynamic changes, and impaired renal function. ACS is most often observed in critically ill patients with peritonitis, gastric dilatation, intestinal(More)
Background Oncolytic viruses are a promising approach for cancer therapy. Recent clinical trials proved the safety and antitumor activity of several oncolytic viruses in solid tumors. However, very little is known about the potential of the oncolytic viruses to target hematologic malignancies. Careful analysis of the effects of the oncolytic viruses in(More)
Oncolytic vaccinia virus (VACV) therapy is an alternative cancer treatment modality that mediates targeted tumor destruction through a tumor-selective replication and an induction of anti-tumor immunity. We developed a humanized tumor mouse model with subcutaneous human tumors to analyze the interactions of VACV with the developing tumors and human immune(More)
BACKGROUND Recent reports emphasize the important role of oxidative stress in the genesis of many syndromes and diseases. The ICU patients have prerequisites for activation of oxidative stress process: activation of the neutrophils, macrophages, and other cells which are capable of producing reactive oxygen species (ROS). The traditional opinion was that(More)