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Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus

• Kevin Lee, Jaewook Jeong, +8 authors Francesco J. Demayo
• Nature Genetics
• 2006

The hedgehog family of morphogens are regulators of cell proliferation, differentiation and cell-cell communication. These morphogens have been shown to have important roles in organogenesis,… (More)

Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D.

• Reinhold G. Erben, Desi W Soegiarto, +6 authors Rudi Balling
• Molecular endocrinology
• 2002

The vitamin D hormone 1,25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)], the biologically active form of vitamin D, is essential for an intact mineral metabolism. Using gene targeting, we sought to… (More)

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP.

• Tatsuya Kobayashi, Desi W Soegiarto, +4 authors Henry M. Kronenberg
• The Journal of clinical investigation
• 2005

In the developing growth plate, periarticular chondrocytes proliferate, differentiate into columnar chondrocytes, and then further differentiate into postmitotic hypertrophic chondrocytes.… (More)

Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation.

• Mohammed Shawkat Razzaque, Desi W Soegiarto, Da Chun Chang, Fanxin Long, Beate Lanske
• The Journal of pathology
• 2005

Indian hedgehog (Ihh) is actively involved in endochondral bone formation. Although expression of Ihh is mostly restricted to pre-hypertrophic chondrocytes, the role of chondrocyte-derived Ihh in… (More)

Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor.

• Ute Zeitz, Karin Weber, Desi W Soegiarto, Eckhard Wolf, Rudi Balling, Reinhold G. Erben
• FASEB journal : official publication of the…
• 2003

It was the aim of this study to further explore the functional role of vitamin D in the endocrine pancreas. By gene targeting, we have recently generated mice in which a lacZ reporter gene is driven… (More)

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