Desheng Huang

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MOTIVATION Because co-expressed genes are likely to share the same biological function, cluster analysis of gene expression profiles has been applied for gene function discovery. Most existing clustering methods ignore known gene functions in the process of clustering. RESULTS To take advantage of accumulating gene functional annotations, we propose(More)
BACKGROUND A reliable and precise classification is essential for successful diagnosis and treatment of cancer. Gene expression microarrays have provided the high-throughput platform to discover genomic biomarkers for cancer diagnosis and prognosis. Rational use of the available bioinformation can not only effectively remove or suppress noise in gene chips,(More)
Genetic variants of ABCB1 gene contributed to cancer susceptibility and interindividual differences in chemotherapy response. Therefore, we investigated the relevance between genetic variations in ABCB1 gene and both risk and clinical outcomes of breast carcinoma. A case–control study was performed on the SNPs C3435T, C1236T and G2677T/A in 1,173 Chinese(More)
AIM To study the application of artificial neural network (ANN) in forecasting the incidence of hepatitis A, which had an autoregression phenomenon. METHODS The data of the incidence of hepatitis A in Liaoning Province from 1981 to 2001 were obtained from Liaoning Disease Control and Prevention Center. We used the autoregressive integrated moving average(More)
BACKGROUND The effects of climate variations on bacillary dysentery incidence have gained more recent concern. However, the multi-collinearity among meteorological factors affects the accuracy of correlation with bacillary dysentery incidence. METHODS As a remedy, a modified method to combine ridge regression and hierarchical cluster analysis was proposed(More)
BACKGROUND HFRS is a serious public health problem in China and the study on HFRS is important in China for its large population. The present study aimed to explore the impact of climatic variables and reservoir on the incidence of HFRS in Huludao City, an epidemic focus of the disease in northeastern China. METHODS Structure Equation Model (SEM), a(More)
OBJECTIVES The shortage of qualified nurses is one of the critical challenges in the field of healthcare. Among the contributing factors, job burnout has been indicated as a risk factor for the intention to leave. The purpose of this study was to provide a better understanding of the local status and reference data for coping strategies for intensive care(More)
OBJECTIVE To understand the influence of the hOGG1 Ser326Cys polymorphism on lung cancer susceptibility, an updated meta-analysis was performed. METHODS A total of 7,592 patients and 8,129 controls from 18 studies, identified by searching ISI Web of Knowledge, PubMed, EMBase and CNKI database up to January 2011, were included. Unconditional multivariable(More)
The relationship between the incidence of bacillary dysentery and meteorological factors was investigated. Data on bacillary dysentery incidence in Shenyang from 1990 to 1996 were obtained from Liaoning Provincial Center for Disease Control and Prevention, and meteorological data such as atmospheric pressure, air temperature, precipitation, evaporation,(More)
OBJECTIVE Many countries carry a high cancer burden and comprehensive cancer nursing is becoming increasingly complicated and difficult. Summarizing the recent research focus on cancer nursing may provide a snapshot of this field for those nurses or nurse educators who are in need of a quick overview of the research and its utilization. METHODS Candidate(More)