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A novel parametric model-based method was developed to quantify epicardial conduction patterns and velocity in an isolated Langendorff-perfused rabbit heart. The method incorporated geometric and anatomical features of the left and right ventricles into the analysis. Optical images of propagation were obtained using the voltage-sensitive dye DI-4-ANEPPS,(More)
Optical imaging of cardiac electrical activity using a voltage-sensitive dye provides high spatial resolution maps of action potential propagation and repolarization. Charge-coupled-device (CCD) camera-based imaging systems, however, are limited by their low signal-to-noise ratio. We have developed an image processing method to enhance the quality of(More)
INTRODUCTION Mechanical stimulation can induce electrophysiologic changes in cardiac myocytes, but how mechanoelectric feedback in the intact heart affects action potential propagation remains unclear. METHODS AND RESULTS Changes in action potential propagation and repolarization with increased left ventricular end-diastolic pressure from 0 to 30 mmHg(More)
Following a step increase in sarcomere length, isometric cardiac muscle tension increases instantaneously by the Frank-Starling mechanism. In isolated papillary muscle and myocytes, there is an additional significant rise in developed tension over the following 15 min due to an unknown mechanism. This slow change in tension could not be explained by(More)
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