Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.
- Luigi A Warren, Philip D. Manos, Derrick J. Rossi
- BiologyCell Stem Cell
- 5 November 2010
Cell intrinsic alterations underlie hematopoietic stem cell aging.
- Derrick J. Rossi, D. Bryder, I. Weissman
- BiologyProceedings of the National Academy of Sciences…
- 28 June 2005
Estimation of cell intrinsic functional and molecular properties of highly purified long-term hematopoietic stem cells from young and old mice found that LT-HSC aging was accompanied by cell autonomous changes, including increased stem cell self-renewal, differential capacity to generate committed myeloid and lymphoid progenitors, and diminished lymphoid potential.
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
- Derrick J. Rossi, D. Bryder, J. Seita, A. Nussenzweig, J. Hoeijmakers, I. Weissman
- BiologyNature
- 7 June 2007
Although deficiencies in several genomic maintenance pathways did not deplete stem cell reserves with age, stem cell functional capacity was severely affected under conditions of stress, leading to loss of reconstitution and proliferative potential, diminished self-renewal, increased apoptosis and, ultimately, functional exhaustion.
Somatic coding mutations in human induced pluripotent stem cells
It is shown that 22 human induced pluripotent stem (hiPS) cell lines reprogrammed using five different methods each contained an average of five protein-coding point mutations in the regions sampled, and that hiPS cells acquire genetic modifications in addition to epigenetic modifications.
Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.
- C. Pronk, Derrick J. Rossi, D. Bryder
- BiologyCell Stem Cell
- 11 October 2007
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
- I. Beerman, D. Bhattacharya, Derrick J. Rossi
- BiologyProceedings of the National Academy of Sciences
- 23 March 2010
Data is presented supporting a model in which clonal expansion of a class of intrinsically myeloid-biased HSCs with robust self-renewal potential is a central component of hematopoietic aging.
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
- W. Pang, E. Price, I. Weissman
- Biology, MedicineProceedings of the National Academy of Sciences
- 28 November 2011
Age-associated alterations in the frequency, developmental potential, and gene expression profile of human HSC are similar to those changes observed in mouse HSC, suggesting that hematopoietic aging is an evolutionarily conserved process.
Human iPSC-based modeling of late-onset disease via progerin-induced aging.
- Justine D. Miller, Y. Ganat, L. Studer
- BiologyCell Stem Cell
- 5 December 2013
Stems Cells and the Pathways to Aging and Cancer
- Derrick J. Rossi, C. Jamieson, I. Weissman
- Biology, MedicineCell
- 22 February 2008
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