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BACKGROUND The increasing global burden of tuberculosis (TB) is linked to human immunodeficiency virus (HIV) infection. METHODS We reviewed data from notifications of TB cases, cohort treatment outcomes, surveys of Mycobacterium tuberculosis infection, and HIV prevalence in patients with TB and other subgroups. Information was collated from published(More)
Despite policies, strategies, and guidelines, the epidemic of HIV-associated tuberculosis continues to rage, particularly in southern Africa. We focus our attention on the regions with the greatest burden of disease, especially sub-Saharan Africa, and concentrate on prevention of tuberculosis in people with HIV infection, a challenge that has been greatly(More)
BACKGROUND Much concern has been expressed about the high prevalence of tuberculosis in prisons in industrialised countries. Since there is almost no information from developing countries, we investigated the rate of pulmonary tuberculosis in a large prison in Malawi. METHODS Between May and July, 1996; we carried out an active case-finding survey in(More)
PREFACE The World Health Organization's Stop TB Department has prepared this third edition of Treatment of tuberculosis: guidelines for national programmes with the help of the International Union Against Tuberculosis and Lung Disease and experts worldwide. The aim is to give practical guidance to national tuberculosis programmes (NTPs) and the medical(More)
Granulocyte colony-stimulating factor (G-CSF) was administered by continuous subcutaneous infusion to 15 patients with non-myeloid malignancies treated by high-dose chemotherapy and autologous bone marrow infusion. G-CSF was given at variable dosage based on neutrophil count. Sustained serum levels of G-CSF were achieved. Neutrophil recovery was accelerated(More)
The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities , or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps(More)
BACKGROUND Data on non-communicable disease (NCD) burden are often limited in developing countries in Africa but crucial for planning and implementation of prevention and control strategies. We assessed the prevalence of related cardiovascular disease risk factors (hyperglycaemia, high blood pressure and obesity) in a longstanding population cohort in rural(More)
BACKGROUND Although in developing countries the burden of morbidity and mortality due to infectious diseases has often overshadowed that due to chronic non-communicable diseases (NCDs), there is evidence now of a shift of attention to NCDs. DISCUSSION Decreasing the chronic NCD burden requires a two-pronged approach: implementation of the multisectoral(More)