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Ubiquitin has previously been identified as a component of neuronal inclusions in neurodegenerative disorders. In this investigation, we examined tissue from cases of Alzheimer's disease (AD), Pick's disease, Parkinson's disease (PD), and progressive supranuclear palsy (PSP) to identify previously unrecognized ubiquitinated structures and to assess the(More)
The immunoreactivity of neurofibrillary tangles (bundles of abnormal filaments) in Alzheimer's disease was compared in photonic and electron microscopy using antisera against the microtubule- associated protein tau, against isolated tangles, against ubiquitin and using monoclonal antibodies against neurofilament proteins. Only a sub-population of tangles is(More)
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