Derek J. Raine

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Y. Grondin, D. J. Raine Centre for Interdisciplinary Science, Department of Physics and Astronomy, University of Leicester, Leicester LE1 7RH, UK iscience@le.ac.uk and V. Norris Assemblages Moléculaires: Modélisation et Imagerie SIMS, FRE CNRS 2829, Faculté des Sciences et Techniques de Rouen, F76821 Mont Saint Aignan, France & Epigenomics Project,(More)
To develop a comprehensive ‘cells-first’ approach to the origin of life, we propose that protocells form spontaneously and that the fission and fusion of these protocells drives the dynamics of their evolution. The fitness criterion for this evolution is taken to be the the stability (conservation) of domains in the protocellular membrane as determined by(More)
To address central problems in the origin of life such as the formation of linear polymers composed of only a small number of types of molecules, we have modeled the distribution of peptides in lipid monolayers. We show that short peptides and amino acids accumulate at the boundary between lipid domains, and that the concentration towards the boundary is(More)
Hyperstructures or modules have been proposed to constitute a level of organisation intermediate between macromolecules and whole cells. In this model of intracellular organisation, hyperstructures compete and collaborate for existence within the membrane and cytoplasm. Those directly involved in the cell cycle include initiation, replication and division(More)
We hypothesize that life began not with the first self-reproducing molecule or metabolic network, but as a prebiotic ecology of co-evolving populations of macromolecular aggregates (composomes). Each composome species had a particular molecular composition resulting from molecular complementarity among environmentally available prebiotic compounds. Natural(More)
Here we discuss proteomic analyses of whole cell preparations of the mosquito stages of malaria parasite development (i.e. gametocytes, microgamete, ookinete, oocyst and sporozoite) of Plasmodium berghei. We also include critiques of the proteomes of two cell fractions from the purified ookinete, namely the micronemes and cell surface. Whereas we summarise(More)
New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We(More)
Five common assumptions about the first cells are challenged by the pre-biotic ecology model and are replaced by the following propositions: firstly, early cells were more complex, more varied and had a greater diversity of constituents than modern cells; secondly, the complexity of a cell is not related to the number of genes it contains, indeed, modern(More)
New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We(More)
networks (or graphs) consist of nodes and links between them. The number of links per node, which we call the class of the node, may vary between nodes, but in a homogeneous network the statistical distribution of links will be the same from region to region across the network. Classically, the distinction amongst homogeneous networks has been made between(More)