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Five common assumptions about the first cells are challenged by the pre-biotic ecology model and are replaced by the following propositions: firstly, early cells were more complex, more varied and had a greater diversity of constituents than modern cells; secondly, the complexity of a cell is not related to the number of genes it contains, indeed, modern(More)
New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We(More)
Here we discuss proteomic analyses of whole cell preparations of the mosquito stages of malaria parasite development (i.e. gametocytes, microgamete, ookinete, oocyst and sporozoite) of Plasmodium berghei. We also include critiques of the proteomes of two cell fractions from the purified ookinete, namely the micronemes and cell surface. Whereas we summarise(More)
The living cell is an autocatalytic network of metabolic pathways sustained far from equilibrium by the supply of matter and energy. At the abstract level we can regard a chart of cellular metabolic pathways as a network of undirected connexions between metabolites (the nodes of the network) each connected pair being related by an enzyme-catalyzed reaction.(More)
The papers in this collection record the talks given at the conference on " Open Questions on the Origin of Life " held in Leicester in May 2012. This was the third such meeting in a series inspired by Professor Luisi with the agenda to discuss open problems and new approaches. The format of the papers presented here broadly keeps to that of the conference,(More)
BACKGROUND Two aspects of genetic regulatory networks are the static architecture that describes the overall connectivity between the genes and the dynamics that describes the sequence of genes active at any one time as deduced from mRNA abundances. The nature of the relationship between these two aspects of these networks is a fundamental question. To(More)